- Lactam antibiotics, in particular penicillins and cephalosporins
have the annual sales of 65% of the total antibiotics market.
Therefore the annual expenditure of penicillin G acylase (PGA) is
estimated to be in the range of 10-30 million tons. PGA
immobilization preparations (both enzyme and cells) to successfully
produce 10,000 tons of total 6-aminopenicillanic acid (6-APA)
provide a novel direction to the antibiotics industries promoting a
safer and cleaner environment. In the present study, different
bacterial samples were isolated from soil of different places of
Dibrugarh and screened for biotransformation ability to produce
6-APA. Among ten of them, three gram positive bacterial samples
designated as AKDD-2, AKDD-4 and AKDD-6 showed the production of
6-APA from penicillin G. Assessment of 6-APA production after
incubation in penicillin G (2mg/ml) by three different samples
separately in free and agar immobilization state was done by HPLC
analysis. Reusability of immobilized cell was found successful up
to 14 days. The work focuses comparison of catalytic properties to
produce 6-APA of some industrially valuable soil microorganisms
entrapped in agar with the free form."
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