Books > Medicine > Pre-clinical medicine: basic sciences > Anatomy
|
Buy Now
Handbook of Transcription Factor NF-kappaB (Hardcover)
Loot Price: R1,594
Discovery Miles 15 940
You Save: R2,990
(65%)
|
|
Handbook of Transcription Factor NF-kappaB (Hardcover)
Expected to ship within 12 - 17 working days
|
Recent evidence proving the molecular link between unchecked,
chronic inflammation and cancer has implicated the transcription
factor NF-kB as a key factor in both inhibiting apoptosis and
promoting cell proliferation. Since its initial identification 20
years ago as a simple regulating factor in one small part of the
immune response, NF-kB is proving to be the most protean of all
transcription factors. It has been shown to function in most cell
types as a key regulator of a number of inducible genes. Research
on the responsibilities and resulting pathologies of NF-kB has been
prolific, but until now there has been no consolidated,
multidisciplinary reference.
Providing contributions from leading authorities involved with
seminal discoveries on the subject, Handbook of Transcription
Factor NF-kappaB is an entry point to understanding the broad role
of this widely studied factor. Beginning with a summary, the
authors introduce the uninitiated reader to the complexities of the
NF-kB system. They explain how a multitude of extracellular and
intercellular signals integrated at the level of this transcription
factor have led to fundamental insights about many aspects of gene
regulation and signal transduction.
The chapters delve into specific research aspects concerning the
function and regulation of NF-kB in a number of biological systems.
They discuss inflammation, innate and adaptive immunity, liver
integrity, and nervous system development, as well as the formation
of hair, skin, teeth, and many other aspects of the developing
vertebrate body. The pathological effects of excess NF-kB activity
are addressed in chapters on diseases related to chronic
inflammation, such as heartdisease, muscular dystrophy, cancer, and
tumor proliferation, as well as diseases caused by inherent
deficiencies in NF-kB. The text culminates in a discussion of
current efforts to develop therapies aimed at inhibiting the
aberrant activity of NF-kB in different diseases.
General
Is the information for this product incomplete, wrong or inappropriate?
Let us know about it.
Does this product have an incorrect or missing image?
Send us a new image.
Is this product missing categories?
Add more categories.
Review This Product
No reviews yet - be the first to create one!
|
|
Email address subscribed successfully.
A activation email has been sent to you.
Please click the link in that email to activate your subscription.