Some novel schiff bases of 3-aminomethyl pyridine and 2-amino
pyridine have been synthesized through condensation reaction with
substituted aryl aldehydes/ketones and/alicyclic ketones. These
schiff bases were screened for anticonvulsant activity,
neurotoxicity and antideprassant activity. The chemical structures
of synthesized compounds were confirmed by FT-IR, 1H-NMR, 13C-NMR
spectroscopy, and elemental analysis. In the preliminary
anticonvulsant screening, three convulsant test models were used:
maximal electro shock (MES), subcutaneous pentylenetetrazole
(sc.PTZ), subcutaneous strychnine (sc.STY) and neurotoxicity screen
(rotorod method in mice). Protective index (PI) is considered an
index of the margin of safety and tolerability between
anticonvulsant doses and doses of various synthesized compounds
exerting acute adverse effects. In Phase-II screening in mice ED50
and TD50 and PI were determined. Some selected compounds were
subjected to oral MES screen in rats and were found effective
against MES test.
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