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Interaction of Pioglitazone and Metformin with Naproxen and Ibuprofen (Paperback)
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Interaction of Pioglitazone and Metformin with Naproxen and Ibuprofen (Paperback)
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The principle purpose of the present study was to investigate in
vitro complex formation and to study the nature and strength of
complexes which could be formed due to interaction of Metformin or
Pioglitazone with Naproxen and Ibuprofen. Metformin and
Pioglitazone are anti-diabetic drugs; Metformin is the first-line
drug of choice for the treatment of type 2 diabetes, particularly
in overweight and obese people and those with normal kidney
function. Pioglitazone is an anti-diabetic drug
(thiazolidinedione-type, also called "glitazones") used along with
a proper diet and exercise program to control high blood sugar in
patients with type 2 diabetes (noninsulin- dependent diabetes). It
works by helping to restore your body's proper response to insulin,
thereby lowering your blood sugar. On the other side, Naproxen and
Ibuprofen, both are NSAIDs, commonly used for the reduction of
pain, fever, inflammation and stiffness caused by conditions such
as osteoarthritis, kidney stones, rheumatoid arthritis, psoriatic
arthritis, gout, ankylosing spondylitis, menstrual cramps,
tendinitis, bursitis, and the treatment of primary dysmenorrhea. It
works by inhibiting both the COX-1 and COX-2 enzyme
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