The objective of transdermal delivery system is to achieve optimum
therapeutic management. But, it still remains a challenge in the
field of pharmaceuticals for delivery of ionic species such as
proteins and peptides. Development of iontophoretic system is a
breakthrough in this field designed to improve the delivery rate of
ionic compounds. This technique generates an electrical potential
gradient that facilitates the movement of solute ions across the
membrane. Iontophoresis is the process of increasing the
penetration of drugs into the skin by application of an electric
current. The drug is applied under an electrode of the same charge
as the drug, and a return electrode opposite in charge to the drug
is placed at a neutral site on the body surface. Electrical energy
assists the movement of ions across the skin using the principle
"like charges repel each other and opposite charges attract."
Iontophoresis seems to be an ideal candidate to sort out the
limitations associated with the delivery of ionic drugs. In this
book, efforts have been made to summarize all the aspects of
iontophoretic delivery.
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