Extensively revised and updated, Antisense Drug Technology:
Principles, Strategies, and Applications, Second Edition reflects
the logarithmic progress made in the past four years of
oligonucleotide-based therapies, and, in particular, antisense
therapeutics and research. Interpreting lessons learned from the
clinical trials of first generation drugs, the book evaluates the
technology as a whole and offers new directions and avenues of
research and development.
Divided into five parts, the book begins with a thorough
introduction to the mechanism of antisense drug action including
the RNase H mechanism, small RNA silencing pathways, and the
potential therapeutics of splice switching oligonucleotides.
Leading researchers demonstrate the basics of oligonucleotide
therapeutics in part two by delineating medicinal chemistry,
pharmacokinetics, and delivery routes such as liposomal
formulations for nucleic acid delivery. Part three details
hybridization based drugs and considers the dramatic advances
represented by 2' methoxyethyl chimeric antisense inhibitors and
duplex RNA drugs. Other chemical classes of drugs and mechanisms of
action are described in part four with further discussions on
improving the second generation antisense drugs. The final part
delves deeply into therapeutic applications. Contributing authors
examine the potential of antisense drugs for the alleviation of
cardiovascular diseases, metabolic diseases, inflammatory diseases,
cancer, neurological disorders, and immune modulation.
Presenting a highly detailed, lucid discussion of the remarkable
advances in the field, Antisense Drug Technology: Principles,
Strategies, and Applications, Second Edition provides theplatform
for researchers to continue to aggressively pursue the great
opportunity represented by this exciting technology.
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