Regulation of the Kruppel-like Factor 6 Tumor Suppressor (Paperback)

KLF6 is a ubiquitously expressed Krppel-like transcription factor whose role in vitro and in vivo role has not been fully identified. Like other members of the Krppel-like family, KLF6 contains a conserved iterminal three zinc finger DNA-binding domain (C2H2 motifs) and a unique N-terminal transactivation domain. KLF6 directly binds DNA at GC box promoter elements. Transcriptional targets of KLF6 include collagen 1, transforming growth factor beta 1 (TGF1), types I and II TGF receptors, urokinase type plasminogen activator (uPA), and the human immunodeficiency virus long terminal repeat (HIV-1 LTR). Here, we identify a novel mechanism of carcinogenesis, whereby oncogenic Ras signaling enhances alternative splicing-mediated inactivation of the KLF6 tumor suppressor in hepatocellular carcinomas. These Ras-dependent splice forms are shown to abrogate KLF6-mediated growth suppression, and ectopic KLF6 splice variant expression can restore a Ras-transformed phenotype.

General

Imprint:	VDM Verlag
Country of origin:	Germany
Release date:	November 2008
First published:	November 2008
Authors:	Steven Yea • Scott L. Friedman
Dimensions:	229 x 152 x 9mm (L x W x T)
Format:	Paperback - Trade
Pages:	168
ISBN-13:	978-3-639-10335-9
Categories:	Books > Medicine > General issues > General Promotions
LSN:	3-639-10335-1
Barcode:	9783639103359

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