The power of stem cells for tissue development, regeneration, and
renewal has been well known by embryologists and developmental
biologists for many years. Those presently active in research in
the stem cell field owe much to previous work by embryologists and
cancer researchers for their insights into what stem cells can do.
In the last 4- 5 years, the rapid expansion of the concept of adult
tissue stem cells as pluripotent progenitors for various tissues
has led to an even greater appreciation of the power of stem cells.
The demonstration that both embryonic and adult tissue stem cells
have the ability to produce progenitor cells for tissue renewal has
opened vast possibilities for treatment of congenital deficiency
diseases as well as for regeneration of damaged tissues. Older
concepts of determination leading to loss of potential during
differentiation of adult tissues are being replaced by newer ideas
that cells with multiple potential exist in different forms in
various adult organs and that cells thought to be restricted to
differentiation to one cell type may be able to
"transdifferentiate" into other tissue cell types. Thus, the
concept of "embryonic rests" in adult tissues, hypothesized to be
the cellular origin of cancer by Durante and Conheim in the 1870s,
now can be expanded to include survival of pluripotential
embryonic-like stem cells in adult tissues.
General
Imprint: |
HumanaPress
|
Country of origin: |
United States |
Release date: |
December 2010 |
First published: |
2004 |
Editors: |
Stewart Sell
|
Dimensions: |
279 x 210 x 26mm (L x W x T) |
Format: |
Paperback
|
Pages: |
509 |
Edition: |
Softcover reprint of hardcover 1st ed. 2004 |
ISBN-13: |
978-1-61737-367-1 |
Categories: |
Books >
Medicine >
Pre-clinical medicine: basic sciences >
Medical genetics
|
LSN: |
1-61737-367-2 |
Barcode: |
9781617373671 |
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