Metformin matrix and gastro retentive tablets formulations were
prepared with different compositions. Finally, one optimized
formula for each, matrix and gastro retentive, were selected and
studied in detail. The effect of formulation variables namely,
process of manufacturing, different excipients, different polymers,
and concentration of polymer were studied. Metformin release was
inversely proportional to the polymer concentration. Drug release
from the developed formulations was independent of pH of the
release medium but dependent on the agitational intensity, hardness
of tablet, and surface area of tablet. Metformin release from both
developed matrix and gastro retentive formulations follows first
order. The manufacturing procedure was found to be reproducible and
formulations were stable after one month of accelerated stability
studies.
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