Amlodipine used as an anti-hypertensive and in the treatment of
angina. FDT of amlodipine besylate were prepared using different
superdisintegrants by direct compression method. Mannitol was used
as a diluent. Aspartame and Acesulfame Potassium were used for
unpleasant taste masked from the amlodipine by cosifting and serial
of blending with other excipients. The mixed final blend was then
compressed into tablets. The formulations were evaluated for weight
variation, hardness, friability, wetting time, disintegrating time,
dissolution, taste evaluation study and in vitro dispersion time.
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