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Books > Medicine > Other branches of medicine > Pharmacology
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Development of Sustained Release Tablets of Eplerenone (Paperback)
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Development of Sustained Release Tablets of Eplerenone (Paperback)
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The objective of this work was to develop of a suitable SR tablet
formulation of Eplerenone and to study the effect of polymers such
as HPMC K4M, HPMC K15M, NaCMC, Guar gum, Xanthan gum and Karaya gum
on drug release. Profile and to get an optimized formulation.
Eplerenone binds to the mineralo corticoidreceptorand blocks the
binding of aldosterone, a component of the
renin-angiotensin-aldosterone system (RAAS). It has a half life of
4 hrs. When dose is missing it may cause nocturnal attack, so
attention was made to develop the Sustained release tablets of
Eplerenone. The purpose of controlled release systems is to
maintain drug concentration in the blood or in target tissues at a
desired value as long as possible. In other words, they are able to
exert a control on the drug release rate and duration. In the
market only IR tablets of Eplerenone were available which are
costly. So there is a need to formulate SRMT of Eplerenone to
reduce the cost and increase the patient compliance."
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