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Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins
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Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications (Hardcover, 2014 ed.)
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Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications (Hardcover, 2014 ed.)
Series: Subcellular Biochemistry, 75
Expected to ship within 12 - 19 working days
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The study of carbonic anhydrase has spanned multiple generations of
scientists. Carbonic anhydrase was first discovered in 1932 by
Meldrum and Roughton. Inhibition by sulfanilamide was shown in 1940
by Mann and Keilin. Even Hans Krebs contributed to early studies
with a paper in 1948 showing the relationship of 25 different
sulfonamides to CA inhibition. It was he who pointed out the
importance of both the charged and uncharged character of these
compounds for physiological experiments. The field of study that
focuses on carbonic anhydrase (CA) has exploded in recent years
with the identification of new families and isoforms. The CAs are
metalloenzymes which are comprised of 5 structurally different
families: the alpha, beta, gamma, and delta, and epsilon classes.
The alpha class is found primarily in animals with several isoforms
associated with human disease. The beta CAs are expressed primarily
in plants and are the most divergent. The gamma CAs are the most
ancient. These are structurally related to the beta CAs, but have a
mechanism more similar to the alpha CAs. The delta CAs are found in
marine algae and diflagellates. The epsilon class is found in
prokaryotes in which it is part of the carboxysome shell perhaps
supplying RuBisCO with CO2 for carbon fixation. With the excitement
surrounding the discovery of disease-related CAs, scientists have
redoubled their efforts to better understand structure-function
relationships, to design high affinity, isotype-specific
inhibitors, and to delineate signaling systems that play regulatory
roles over expression and activity. We have designed the book to
cover basic information of mechanism, structure, and function of
the CA families. The authors included in this book bring to light
the newest data with regard to the role of CA in physiology and
pathology, across phylums, and in unique environmental niches.
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