Long before the U.S. government began conducting secret radiation
and germ-warfare experiments, and long before the Tuskegee syphilis
experiments, medical professionals had introduced-and hotly debated
the ethics of-the use of human subjects in medical experiments. In
Subjected to Science, Susan Lederer provides the first full-length
history of biomedical research with human subjects in the earlier
period, from 1890 to 1940. Lederer offers detailed accounts of
experiments-benign and otherwise-conducted on both healthy and
unhealthy men, women, and children, including the yellow fever
experiments (which ultimately became the subject of a Broadway play
and Hollywood film), Udo Wile's "dental drill" experiments on
insane patients, and Hideyo Noguchi's syphilis experiments, which
involved injecting a number of healthy children and adults with the
syphilis germ, luetin.
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