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Signaling-Mediated Control of Cell Division - From Oogenesis to Oocyte-to-Embryo Development (Hardcover, 1st ed. 2017)
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Signaling-Mediated Control of Cell Division - From Oogenesis to Oocyte-to-Embryo Development (Hardcover, 1st ed. 2017)
Series: Results and Problems in Cell Differentiation, 59
Expected to ship within 12 - 17 working days
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This volume covers the current knowledge base on the role of
signaling and environmental pathways that control the normal
development of germline stem cells, meiotic progression of oocytes,
events of oocyte maturation and fertilization, and the birth of an
embryo. Germ cells are uniquely poised to sustain life across
generations through the fusion of oocyte and sperm. Because of the
central importance of germ cells to life, much work has been
dedicated to obtaining a clear understanding of the molecular and
signaling events that control their formation and maintenance. Germ
cells are set aside from somatic cells in the embryo and go through
specialized meiotic cell cycles as the animal matures. These cell
cycles are interspersed with long periods of arrest. In human
females, meiosis I is initiated in the fetus. At birth, oocytes are
arrested in meiosis I; after puberty, every month an oocyte
initiates meiosis II - ovulation. Upon sperm availability these
cells are fertilized, generate an embryo, and the cycle-of-life
continues. During meiotic I progression and arrest, the fitness of
oocytes and their progeny are likely influenced by environmental
cues and signaling pathways. A lot of recent work has focused on
understanding the mechanisms that regulate oocyte fitness and
quality in humans and vertebrates. Much of our understanding on the
events of meiosis I and germline stem cell populations comes from
work in invertebrates, wherein the germline stem cells produce
oocytes continuously through adult development. In both inverbrates
and vertebrates nutritional and signaling pathways control the
regulation of stem cells in such a manner so as to couple
production of gametes with the nutritional availability.
Additionally, mature oocytes arrest both in meiosis I and meiosis
II, and signaling and nutritional pathways have been shown to
regulate their formation, and maintenance, such that despite long
periods of arrest, the oocyte quality is assured and errors in
chromosome segregation and varied cytoplasmic events are minimal.
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