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Antimicrobial Prophylaxis in Urology with special reference to the new Quinolones (Paperback, Softcover reprint of the original 1st ed. 1992)
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Antimicrobial Prophylaxis in Urology with special reference to the new Quinolones (Paperback, Softcover reprint of the original 1st ed. 1992)
Series: Fortschritte der Urologie und Nephrologie, 27
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This monograph gives an excellent review of the issue of
antimicrobial prophylaxis in urol ogy and the use of the new
fluoroquinolones in urology. The development of the fluoro
quinolones has had a profound effect in urology, specifically
because of the unique phar macokinetics of the fluoroquinolones
with their two or more pK values, making concen tration of these
compounds possible in the prostate. Their wide spectra against
infecting organisms causing infections in the urinary tract have
also made them popular and almost ideal in the treatment of urinary
tract infections. This thesis summarizes in an concise way and
brings up to date practically all our know ledge concerning the use
of fluoroquinolones in urology. The chapter on antimicrobial
prophylaxis covers our present knowledge completely, especially
concerning the use of these drugs in antimicrobial prophylaxis in
transurethral surgery. September 1992 PaulO. Madsen Madison,
Wisconsin, USA v Contents Preface. . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . V I.
Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . 1 1. 1. Author's Publications
Referred to in Text . . . . . . . . . . . . . . . . . . . . . . 1
1. 2. Historical Background . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . 1 1. 3. Problems of Antimicrobial
Prophylaxis in Urology . . . . . . . . . . . . . . . . 2 D. General
Considerations . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . 3 2. 1. Definitions . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . 3 2. 1. 1.
Bacteriuria and urinary tract infections . . . . . . . . . . . . .
. . . . . . . . . 3 2. 1. 2. Bacteremia and septicemia . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . 3 2. 1. 3.
Nosocomial infections . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . 4 2. 1. 4. Wound infections . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . 5 2. 2.
Pathophysiology of Infection . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . 5 2. 3. Specifics of Antimicrobial Agents to
be Used in Prophylaxis . . . . . . . . . . 6 2. 4. Role of
Quinolones . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . 6 2. 4. 1. Antimicrobial activity . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . 6 2. 4. 2.
Pharmacokinetic properties . . . . . . . . . . . . . . . . . . . .
. . . . . . . . ."
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