In this research work sustained release Diclofenac Sodium matrix
tablets were prepared by using different polymers like Kollidon SR,
Poly Ethylene Glycol and HPMC at different percentages. 5 batches
of 260mg tablets were prepared by direct compression and wet
granulation methods and by using different shapes in an attempt
towards modification of dissolution behavior of the drug. The used
shapes of tablets were caplet oval, round oval add flat oval.
Dissolution study of each of the formulation was monitored at pH
1.2, 6.5 and 7.4. An increase drug release took place in case of
higher pH i.e. at pH 7.4 & pH 6.5 but in lower pH i.e. at pH
1.2 a little amount of drug release was obtained. Due to the acidic
nature if drug its release was lower at acidic pH. Again in case of
shape at higher pH 6.5 & 7.4 the release was better from the
caplet oval shape than that of round oval and flat oval. A
cooperative higher release of drug was obtained from the polymer
HPMC at 10% from the Diclofenac Sodium matrix tablet, which contain
fixed amount of Kollidon SR, which was 30% them that of the PEG of
10%. The drug release was also found to be better in case of direct
compression method.
General
Imprint: |
Lap Lambert Academic Publishing
|
Country of origin: |
Germany |
Release date: |
2012 |
First published: |
2012 |
Authors: |
Tajnin Ahmed
|
Dimensions: |
229 x 152 x 8mm (L x W x T) |
Format: |
Paperback - Trade
|
Pages: |
128 |
ISBN-13: |
978-3-8473-3689-1 |
Categories: |
Books >
Medicine >
Other branches of medicine >
Pharmacology >
General
|
LSN: |
3-8473-3689-4 |
Barcode: |
9783847336891 |
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