Current knowledge concerning both morphological and functional
cryptorchid-related alterations in the various testicular
compartments is summarized in this valuable new publication. Damage
to the germinal epithelium and resulting infertility in both humans
and experimental animals as well as the degree of damage to the
different stages of germ cell development is discussed. In
addition, information concerning hormonal therapy and orchidopexy
to reverse cryptorchid-related damage is provided. Morphological
alterations in Sertoli and Leydig cells is discussed in terms of
cellular hypertrophy and hyperplasia, alterations in organelle
number and characteristics as well as changes in cell-cell
junctional complexes. Changes in Sertoli cell and Leydig cell
function, including gonadotropin binding, steroidogenesis and other
metabolic alterations is also outlined, as well as the influence of
altered testicular function on subsequent hypothalamic-pituitary
changes. Vascular disruption, the potential role of paracrine
substances and direct thermal damage, all of which may be
responsible for the resulting detrimental changes in one or more
testicular compartments, are considered.
General
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