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Advances in General and Cellular Pharmacology - Volume 1 (Paperback, Softcover reprint of the original 1st ed. 1976)
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Advances in General and Cellular Pharmacology - Volume 1 (Paperback, Softcover reprint of the original 1st ed. 1976)
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Knowledge of the mechanism of action of drugs at cellular,
subcellular, or molecular levels is of vital importance not only in
giving the basis of inter pretation of the systemic action of drugs
but also in improving existing drugs; in designing new forms of
drugs; and in giving the basis of therapeutic applications.
Classical pharmacology, concerning the action of drugs at
integrated levels, does not necessarily give sufficient information
as to the mechanism of action of drugs. A variety of sophisticated
concepts utilizing the methods of physics, chemistry, biophysics,
biochemistry, and physiology must be synthesized to understand the
mechanism of action. Only since the last decade, however, have
these techniques been fully applied to pharma cological
investigations. It is of utmost importance to realize that a new
dimension of pharmacological research has indeed emerged as a
result of such a multidisciplinary approach; this approach is
encompassed in general and cellular pharmacology. Such recent
studies of drug actions have led to a number of important findings.
Certain chemicals and drugs were found to possess highly specific
actions on cellular functions, so that they are widely being used
as powerful tools for the study of a variety of physiological and
pharmacological prob lems. Our knowledge of the cellular mechanisms
of drug action has provided the basis for interpreting the systemic
effects of the drugs and insight into the molecular mechanism
involved.
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