Textbook of "in vivo" Imaging in Vertebrates.
Editors.
Vasilis Ntziachristos
Department of Radiology, Harvard University HMS/MGH,
Charlestown, USA
Anne Leroy-Willig
U2R2M, CNRS and Universite Paris-Sud, Orsay, France
Bertrand Tavitian
Unite d'Imagerie de l'Expression des Genes, INSERM, Orsay,
Franc
This book describes the new imaging techniques being developed
to monitor physiological, cellular and subcellular function within
living animals. This exciting field of imaging science brings
together physics, chemistry, engineering, biology and medicine to
yield powerful and versatile imaging approaches. By combining
advanced non-invasive imaging technologies with new mechanisms for
visualizing biochemical events and protein and gene function,
non-invasive vertebrate imaging enables the in vivo study of
biology and offers rapid routes from basic discovery to drug
development and clinical application. Combined with the
availability of an increasing number of animal models of human
disease, and the ability to perform longitudinal studies of disease
evolution and of the long-term effects of therapeutic procedures,
this new technology offers the next generation of tools for
biomedical research.
Well illustrated, largely in colour, the book reviews the most
common and technologically advanced methods for vertebrate imaging,
presented in a clear, comprehensive format. The basic principles
are described, followed by several examples of the use of imaging
in the study of living multicellular organisms, concentrating on
small animal models of human diseases. The book illustrates:
- The types of information that can be obtained with modern in
vivo imaging;
-The substitution of imaging methods for more destructive
histological techniques;
- The advantages conferred by in vivo imaging in building a more
accurate picture of the response of tissues to stimuli over time
while significantly reducing the number of animals required for
such studies.
Part 1 describes current techniques in in vivo imaging,
providing specialists and laboratory scientists from all
disciplines with clear and helpful information regarding the tools
available for their specific research field. Part 2 looks in more
detail at imaging organ development and function, covering the
brain, heart, lung and others. Part 3 describes the use of imaging
to monitor various new types of therapy, following the reaction in
an individual organism over time, e.g. after gene or cell
therapy.
Most chapters are written by teams of physicists and biologists,
giving a balanced coherent description of each technique and its
potential applications.
The book is aimed at a broad audience conducting research in
areas such as biochemistry, physiology, developmental biology,
oncology and pharmacology. While written primarily for those
already engaged in imaging studies, it will also be of interest to
scientists from other disciplines looking for an entry point into
the field of in vivo imaging in small animals.
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