This volume is the third in a series entitled" Advanced Methods of
Physiological System Modeling" and the fifth in a series of
research volumes published by Plenum under the sponsorship of the
Biomedical Simulations Resource (BMSR) at the Uni versity of
Southern California in the context of dissemination activities
supported by the Biomedical Research Technology Program of the
National Center for Research Resources at the National Institutes
of Health under Grant No. P41 RR-OI861. These volumes are edited by
BMSR principal scientists and report on recent research de
velopments in the area of physiological systems modeling, as well
as on advanced methods for analysis of physiological signals and
data. As in the previous two volumes of this series, the work
reported herein is con cerned with the development of advanced
modeling methodologies and their novel application to problems of
biomedical interest, with emphasis on nonlinear aspects of
physiological function. The term "advanced methodologies" is used
to indicate that the scope of this work extends beyond the ordinary
type of analysis, which is confined traditionally to the linear
domain. As the importance of nonlinearities in understanding the
complex mechanisms of physiological function is increasingly
recognized, the need for effective and practical modeling
methodologies that address the issue of nonlinear dynamics in life
sciences becomes more and more pressing.
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