The aim of this study was to develop a depot formulation of
mirtazapine by w/o emulsification method using chitosan as
controlled release biodegradable polymer. Chitosan microspheres are
used to provide controlled release of mirtazapine and to improve
the bioavailability of degradable substances or enhance the uptake
of hydrophilic substances across the epithelial layers. The effect
of various parameters, such as stirring rate, drug to chitosan
ratio, chitosan concentration and glutaraldehyde concentration on
entrapment efficiency and release study was studied. Stirring speed
affects the size of microspheres, drug to chitosan ratio and
chitosan concentration affects the entrapment efficiency and
release study; glutaraldehyde concentration affects the release of
the drug molecule from the microspheres.
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