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Current Topics in Microbiology and Immunology / Ergebnisse der Mikrobiologie und Immunitatsforschung - Volume 61 (Paperback, Softcover reprint of the original 1st ed. 1973)
Loot Price: R2,776
Discovery Miles 27 760
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Current Topics in Microbiology and Immunology / Ergebnisse der Mikrobiologie und Immunitatsforschung - Volume 61 (Paperback, Softcover reprint of the original 1st ed. 1973)
Series: Current Topics in Microbiology and Immunology, 61
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At the end of the last century and the beginning of this century,
the prob lems of immunity in lower vertebrates and the influence of
environmental temperature attracted attention for the first time
(ERNST, 1890; WIDAL and SICARD, 1897; METCHNIKOFF, 1901). However,
relatively little work has been done on this subject until
recently. The early investigators were chiefly in terested in the
immuno-pathological problems. They immunized various species of
lower vertebrates essentially with bacterial vaccines;
agglutinating, neutralizing and protective antibodies were detected
in their blood. The in fluence of environmental temperature on the
immune response was investigated, since this subject represented
great economical and theoretical importance. Epizootic diseases
were observed to occur in relation to the cold season of the year,
when the decrease or spontaneous increase of water temperature
occurred (SCHAPERCLAUS, 1965; BESSE et al. , 1965; KLONTZ et al. ,
1965 WOOD,1966). The immunological deficiency of fish, caused by
their natural or experimental stay in cold water, is now evident
for both humoral and cellular immunity. In this review we will
focus on two points: We shall attempt (1) to explain the mechanism
by which the environmental temperature influences the immune
resistance of fish to pathogens, (2) to determine the chronological
location of this temperature-sensitive stage in the process of
antibody formation, and to make some approaches to the general
antibody formation mechanism.
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