Over the past few decades an exceedingly large number of
experimental and clinical investigations have been performed in an
attempt to analyze the way in which the kidney functions. The basis
for all this work was established during the nineteenth and the
early twentieth century by morphologists (Bowman 1842; Hyrtl1863,
1872; Heidenhain 1874; Peter 1909; von Mollendorf 1930). All these
investigators clearly outlined the extremely heterogeneous assembly
of renal tissue and also defined the nephron as the smallest
morphological unit. It was further the merit of these anato- mists
and histologists to preclude quite a number of nephron functions
based merely on their careful observations. Contemporary
histologists have been able to add little to these observations.
Unfortunately with the introduction of physiologic in vivo et situ
studies on kidneys the interest in heterogeneity waned. This lack
of attention was aggravated by the introduction of the clearance
techniques which cannot account for regional differences in the
function of the smallest unit, the nephron. That ana- tomic
heterogeneity has a functional correlate was strongly suggested by
Trueta et al. (1947) and vigorously stimulated a number of studies.
The development of physiologic microtechniques, like micropuncture
and microperfusion of single nephrons, or the perfusion of isolated
nephron portions and electrophysiologic studies, enormously
expanded our knowledge concerning details regarding nephron and
total renal func- tion.
General
Is the information for this product incomplete, wrong or inappropriate?
Let us know about it.
Does this product have an incorrect or missing image?
Send us a new image.
Is this product missing categories?
Add more categories.
Review This Product
No reviews yet - be the first to create one!
Welcome to Loot.co.za!
Sign in / Register |Wishlists & Gift Vouchers |Help | Advanced search
