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Books > Medicine > Surgery > Neurosurgery
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Indwelling Neural Implants - Strategies for Contending with the In Vivo Environment (Paperback)
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Indwelling Neural Implants - Strategies for Contending with the In Vivo Environment (Paperback)
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Despite enormous advances made in the development of external
effector prosthetics over the last quarter century, significant
questions remain, especially those concerning signal degradation
that occurs with chronically implanted neuroelectrodes. Offering
contributions from pioneering researchers in neuroprosthetics and
tissue repair, Indwelling Neural Implants: Strategies for
Contending with the In Vivo Environment examines many of these
challenges, paying particular attention to how the healing of
tissues surrounding an implant can impact the intended use of a
device. The contributions are divided into four sections * Part one
examines wound healing from the initial insertion trauma through
the inflammatory and repair process, explaining how the action of
healing varies throughout different areas of the body. * Part two
considers various performance issues specific to particular implant
components, including those that arise from the chemical,
mechanical, thermal, and electrical impact on surrounding tissues.
It discusses challenges that result from chronic tissue stimulation
and heat effects that occur with on-chip and telemetric processing.
* Part three presents both in vitro and in vivo approaches to
assessing wound healing response to materials. It includes the
contribution of the developer of a chronic hollow fiber membrane
implant who explains how an in vivo model is used to assess
molecular transport in brain tissue surrounding the implant. * The
final section evaluates molecular and materials strategies for
intervening in CNS wound repair and enhancing the electrical
communication between the electrode surface and the surrounding
tissue. It also presents novel approaches to nerve regeneration and
repair.
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