This book explores the role calcium signaling plays in cellular
responses in almost all types of cells including airway smooth
muscle cells. This universal signaling may result from
extracellular calcium influx and/or intracellular calcium release,
which are precisely controlled and regulated by ion channels,
exchangers and/or transporters on the plasmalemmal or sarcoplasmic
reticulum membrane. First, several chapters detail calcium release
channels (ryanodine receptors and inositol trisphosphate
receptors), voltage-dependent potassium channels, transient
receptor potential channels, Orai channels, calcium-activated
potassium channels, and calcium-activated chloride channels.
Well-characterized sodium-calcium exchangers, voltage-dependent
calcium channels, and calcium pumps are described also in depth
over many chapters. Ca2+ signaling can be expressed in Ca2+ sparks,
waves, oscillations, and global changes in intracellular Ca2+
concentration. Calcium in subcellular compartments (cytosol,
sarcoplasmic reticulum, mitochondria, and caveolae) also exhibit
dynamic crosstalk. Many molecules including FK506 binding proteins,
cyclic adenosine diphosphate ribose, reactive oxygen species, RhoA
kinases, caveolin and integrins can modify and induce spatial,
temporal and compartmental variations of calcium signaling. In
addition, calcium signaling can exhibit sex hormone- and
age-dependent changes. A number of chapters are dedicated to
covering these diverse formats, spatiotemporal characteristics,
multifaceted network and mathematical modeling of Ca2+ signaling.
Neurotransmitters, hormones, growth factors, inflammatory
cytokines, and other stimuli may lead to multiple cellular
responses by inducing Ca2+ signaling in airway smooth muscle cells.
Increasing evidence suggests that Ca2+ pumps and canonical
transient receptor potential channels are essential for airway
smooth muscle remodeling. Accordingly, several chapters summarize
recent advances in the studies of the key role of calcium signaling
in physiological cellular responses as well as the development of
asthma, chronic obstructive pulmonary disease and other respiratory
disorders.
General
Is the information for this product incomplete, wrong or inappropriate?
Let us know about it.
Does this product have an incorrect or missing image?
Send us a new image.
Is this product missing categories?
Add more categories.
Review This Product
No reviews yet - be the first to create one!