This book is divided into 5 Chapters in which Chapter 1 contains
introduction on anticancer tyrosine kinase inhibitors, Chapter 2
contains an overview of drug design and quantitative
structure-activity relationship, Chapter 3 contains literature
review, Chapter 4 contains plan of work and methodology and finally
Chapter 5 contains work done and discusses in detail the results
obtained. A quantitative structure-activity relationship (QSAR)
study has been made on some series of anticancer tyrosine kinase
inhibitors, namely, a series of aminopropyl tetrahydroindole-based
indolin-2-ones, a series of pyrrole derivatives, a series of
4-alkynyl and 4-alkenylquinazolines, and a series of
N-4,6-pyrimidine-N-alkyl-N-phenyl ureas. In each series,
significant correlations are found between the inhibition potencies
of specific tyrosine kinases and some physicochemical and steric
properties of the compounds explained by different regression
equations. Docking study was also performed on assumed compounds of
one of the series to find the compound having best interaction with
the receptor."
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