Cytochrome P450 - In Vitro Methods and Protocols (Paperback, 1st ed. 2021)

This collection explores detailed experimental protocols necessary for setting up a variety of in vitro cytochrome P450 (CYP) assays that are vital in selecting drug candidates in a drug discovery pipeline. Major factors affecting drug metabolism include CYP expression levels, kinetic parameters for individual CYP enzymes, CYP inhibition and induction, time-dependent inhibition (TDI), CYP stability, non-CYP stability, UDP-glucuronosyltransferases (UGT) stability, excretion mechanisms, and drug-drug interactions (DDI), all addressed in this volume. Written for the Methods in Pharmacology and Toxicology series, chapters include helpful background information on the in vitro assay, a list of all the materials, reagents, and equipment necessary to carry out the assay, a step-by-step protocol, notes containing common and unexpected experimental problems in the assay, as well as references containing important supplementary reading. Authoritative and practical, Cytochrome P450: In Vitro Methods and Protocols serves as a key guide for researchers in the area of discovery and development of new medicines.

General

Imprint:	Springer-Verlag New York
Country of origin:	United States
Series:	Methods in Pharmacology and Toxicology
Release date:	July 2022
First published:	2021
Editors:	Zhengyin Yan • Gary W. Caldwell
Dimensions:	254 x 178mm (L x W)
Format:	Paperback
Pages:	379
Edition:	1st ed. 2021
ISBN-13:	978-1-07-161544-7
Categories:	Books > Medicine > Other branches of medicine > Pharmacology > General Books > Science & Mathematics > Biology, life sciences > Biochemistry > Enzymology Books > Professional & Technical > Industrial chemistry & manufacturing technologies > Industrial chemistry > Pharmaceutical technology
LSN:	1-07-161544-0
Barcode:	9781071615447

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