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Through the rapid development of proteomics methods and
technologies, an enormous amount of data was created, leading to a
wide-spread rethinking of strategy design and data interpretation.
In Data Mining in Proteomics: From Standards to Applications,
experts in the field present these new insights within the
proteomics community, taking the historical evolution as well as
the most important international standardization projects into
account. Along with basic and sophisticated overviews of proteomics
technologies, standard data formats, and databases, the volume
features chapters on data interpretation strategies including
statistics, spectra interpretation, and analysis environments as
well as specialized tasks such as data annotation, peak picking,
phosphoproteomics, spectrum libraries, LC/MS imaging, and splice
isoforms. As a part of the highly successful Methods in Molecular
Biology(TM) series, this work provides the kind of detailed
description and implementation advice that is crucial for getting
optimal results. Authoritative and cutting-edge, Data Mining in
Proteomics: From Standards to Applications is a well-balanced
compendium for beginners and experts, offering a broad scope of
data mining topics but always focusing on the current
state-of-the-art and beyond.
Do the antitrust laws have a place in the digital economy or are
they obsolete? That is the question raised by the government's
legal action against Microsoft, and it is the question this volume
is designed to answer. America's antitrust laws were born out of
the Industrial Revolution. Opponents of the antitrust laws argue
that whatever merit the antitrust laws may have had in the past
they have no place in a digital economy. Rapid innovation makes the
accumulation of market power practically impossible. Markets change
too quickly for antitrust actions to keep up. And antitrust
remedies are inevitably regulatory and hence threaten to `regulate
business'. A different view - and, generally, the view presented in
this volume - is that antitrust law can and does have an important
and constructive role to play in the digital economy. The software
business is new, it is complex, and it is rapidly moving. Analysis
of market definition, contestibility and potential competition, the
role of innovation, network externalities, cost structures and
marketing channels present challenges for academics, policymakers
and judges alike. Evaluating consumer harm is problematic.
Distinguishing between illegal conduct and brutal - but legitimate
- competition is often difficult. Is antitrust analysis up to the
challenge? This volume suggests that antitrust analysis `still
works'. In stark contrast to the political rhetoric that has
surrounded much of the debate over the Microsoft case, the articles
presented here suggest neither that Microsoft is inherently bad,
nor that it deserves a de facto exemption from the antitrust laws.
Instead, they offer insights - for policymakers, courts,
practitioners, professors and students of antitrust policy
everywhere - on how antitrust analysis can be applied to the
business of making and marketing computer software.
Communications markets have made much progress towards competition
and deregulation in recent years. However, it is increasingly
clear, in the age of the Internet and the digital revolution, that
much more needs to be done, and that new approaches, both at the
Federal Communications Commission and in Congress, will be required
to complete the task. In this volume, the Progress and Freedom
Foundation presents nine papers by communications policy experts
and government policymakers that show how to finish the job of
deregulating communications markets and reforming the FCC. The
Telecommunications Act of 1996 was a landmark piece of legislation
for an industry moving from a monopoly orientation towards
competition, but additional steps are needed to complete the
process of implementing the pro-competitive, deregulatory vision of
the act. Bringing together a group of the caliber represented in
this book makes possible the best recommendations about the exact
nature of those necessary changes. In this volume, the most
difficult and politically-charged hot-button issues involving local
and long distance competition, universal service, spectrum
allocation, program content regulation, and the public interest
doctrine are confronted head-on. As importantly, the authors
recommend specific reform proposals to be considered by the Federal
Communications Commission and Congress. The ideas contained in the
experts' essays were presented and debated at a conference hosted
by The Progress & Freedom Foundation, which was held in
Washington, DC, on December 8, 2000. The Progress & Freedom
Foundation studies the impact of the digital revolution and its
implications for public policy. It conducts research in fields such
as electronic commerce, telecommunications and the impact of the
Internet on government, society and economic growth. It also
studies issues such as the need to reform government regulation,
especially in technology-intensive fields such as medical
innovation, energy and environmental regulation.
This second edition provides new and updated methods on the
principles underlying modern protein analysis, from statistical
issues to gel-based and mass spectrometry-based applications.
Chapters detail protein quantification as basis for realisation of
quantitative studies, gel-based and mass spectrometry-based
quantification techniques, TMT, IPTL, PRM, MALDI Imaging, SILAC,
PTM analysis, DIA, cross-linking, and the up-to-date topics of
software and data analysis. Written in the highly successful
Methods in Molecular Biology series format, chapters include
introductions to their respective topics, lists of the necessary
materials and reagents, step-by-step, readily reproducible
laboratory protocols, and tips on troubleshooting and avoiding
known pitfalls. Authoritative and cutting-edge, Quantitative
Methods in Proteomics, Second Edition aims to provide comprehensive
and competent overview in the important and still growing field of
quantitative proteomics.
Scholarship on the role of religion in American public life has
taken on a new urgency in the increasingly contentious wake of the
attacks of September 11, 2001. This volume brings together an
impressive group of scholars to build on past work and broaden the
scope of this crucial inquiry in two respects: by exploring aspects
of the religion-politics nexus in the United States that have been
neglected in the past, and by examining traditional questions
concerning the religious tincture of American political discourse
in provocative new ways. Essays include examinations of religious
rhetoric in American political and cultural discourse after
September 11th, the impact of religious ideas on environmental
ethics, religion and American law beyond the First Amendment,
religious responses to questions of gay and lesbian rights, the
Church of Jesus Christ of Latter-Day Saints and issues of free
speech and public space in Utah, and the role of religious
institutions and ideas on the political priorities of
African-American and Latino communities. In addition, Religion,
Politics, and American Identity includes introductory and
concluding essays by leading scholars in the field of religion and
politics that assess present and future directions for study.
Scholarship on the role of religion in American public life has
taken on a new urgency in the increasingly contentious wake of the
attacks of September 11, 2001. This volume brings together an
impressive group of scholars to build on past work and broaden the
scope of this crucial inquiry in two respects: by exploring aspects
of the religion-politics nexus in the United States that have been
neglected in the past, and by examining traditional questions
concerning the religious tincture of American political discourse
in provocative new ways. Essays include examinations of religious
rhetoric in American political and cultural discourse after
September 11th, the impact of religious ideas on environmental
ethics, religion and American law beyond the First Amendment,
religious responses to questions of gay and lesbian rights, the
Church of Jesus Christ of Latter-Day Saints and issues of free
speech and public space in Utah, and the role of religious
institutions and ideas on the political priorities of
African-American and Latino communities. In addition, Religion,
Politics, and American Identity includes introductory and
concluding essays by leading scholars in the field of religion and
politics that assess present and future directions for study.
This second edition provides new and updated methods on the
principles underlying modern protein analysis, from statistical
issues to gel-based and mass spectrometry-based applications.
Chapters detail protein quantification as basis for realisation of
quantitative studies, gel-based and mass spectrometry-based
quantification techniques, TMT, IPTL, PRM, MALDI Imaging, SILAC,
PTM analysis, DIA, cross-linking, and the up-to-date topics of
software and data analysis. Written in the highly successful
Methods in Molecular Biology series format, chapters include
introductions to their respective topics, lists of the necessary
materials and reagents, step-by-step, readily reproducible
laboratory protocols, and tips on troubleshooting and avoiding
known pitfalls. Authoritative and cutting-edge, Quantitative
Methods in Proteomics, Second Edition aims to provide comprehensive
and competent overview in the important and still growing field of
quantitative proteomics.
Through the rapid development of proteomics methods and
technologies, an enormous amount of data was created, leading to a
wide-spread rethinking of strategy design and data interpretation.
In Data Mining in Proteomics: From Standards to Applications,
experts in the field present these new insights within the
proteomics community, taking the historical evolution as well as
the most important international standardization projects into
account. Along with basic and sophisticated overviews of proteomics
technologies, standard data formats, and databases, the volume
features chapters on data interpretation strategies including
statistics, spectra interpretation, and analysis environments as
well as specialized tasks such as data annotation, peak picking,
phosphoproteomics, spectrum libraries, LC/MS imaging, and splice
isoforms. As a part of the highly successful Methods in Molecular
Biology (TM) series, this work provides the kind of detailed
description and implementation advice that is crucial for getting
optimal results. Authoritative and cutting-edge, Data Mining in
Proteomics: From Standards to Applications is a well-balanced
compendium for beginners and experts, offering a broad scope of
data mining topics but always focusing on the current
state-of-the-art and beyond.
Do the antitrust laws have a place in the digital economy or are
they obsolete? That is the question raised by the government's
legal action against Microsoft, and it is the question this volume
is designed to answer. America's antitrust laws were born out of
the Industrial Revolution. Opponents of the antitrust laws argue
that whatever merit the antitrust laws may have had in the past
they have no place in a digital economy. Rapid innovation makes the
accumulation of market power practically impossible. Markets change
too quickly for antitrust actions to keep up. And antitrust
remedies are inevitably regulatory and hence threaten to `regulate
business'. A different view - and, generally, the view presented in
this volume - is that antitrust law can and does have an important
and constructive role to play in the digital economy. The software
business is new, it is complex, and it is rapidly moving. Analysis
of market definition, contestibility and potential competition, the
role of innovation, network externalities, cost structures and
marketing channels present challenges for academics, policymakers
and judges alike. Evaluating consumer harm is problematic.
Distinguishing between illegal conduct and brutal - but legitimate
- competition is often difficult. Is antitrust analysis up to the
challenge? This volume suggests that antitrust analysis `still
works'. In stark contrast to the political rhetoric that has
surrounded much of the debate over the Microsoft case, the articles
presented here suggest neither that Microsoft is inherently bad,
nor that it deserves a de facto exemption from the antitrust laws.
Instead, they offer insights - for policymakers, courts,
practitioners, professors and students of antitrust policy
everywhere - on how antitrust analysis can be applied to the
business of making and marketing computer software.
Communications markets have made much progress towards competition
and deregulation in recent years. However, it is increasingly
clear, in the age of the Internet and the digital revolution, that
much more needs to be done, and that new approaches, both at the
Federal Communications Commission and in Congress, will be required
to complete the task. In this volume, the Progress and Freedom
Foundation presents nine papers by communications policy experts
and government policymakers that show how to finish the job of
deregulating communications markets and reforming the FCC. The
Telecommunications Act of 1996 was a landmark piece of legislation
for an industry moving from a monopoly orientation towards
competition, but additional steps are needed to complete the
process of implementing the pro-competitive, deregulatory vision of
the act. Bringing together a group of the caliber represented in
this book makes possible the best recommendations about the exact
nature of those necessary changes. In this volume, the most
difficult and politically-charged hot-button issues involving local
and long distance competition, universal service, spectrum
allocation, program content regulation, and the public interest
doctrine are confronted head-on. As importantly, the authors
recommend specific reform proposals to be considered by the Federal
Communications Commission and Congress. The ideas contained in the
experts' essays were presented and debated at a conference hosted
by The Progress & Freedom Foundation, which was held in
Washington, DC, on December 8, 2000. The Progress & Freedom
Foundation studies the impact of the digital revolution and its
implications for public policy. It conducts research in fields such
as electronic commerce, telecommunications and the impact of the
Internet on government, society and economic growth. It also
studies issues such as the need to reform government regulation,
especially in technology-intensive fields such as medical
innovation, energy and environmental regulation.
Through a variety of primary sources--including speeches, poems,
magazine articles, and book excerpts--this collection illustrates
the origins, ambitions, and political legacy of the American
Progressivism movement (1886-1924). A general introduction offers a
history of the movement and a brief discussion of recent
historiographical debates; headnotes introduce each selection and
provide historical and political context.
Vorliegende Arbeit schliesst an den Untersuchungen von Kunze (1969)
uber die Papilla filiformis des Menschen an, in der aufgrund der
Anwesenheit und Art der Nervenendformationen gezeigt werden konnte,
dass sie vornehmlich der Rezeption der Tastempfindung dient. Diese
Arbeit beschreibt die Morphologie der als pilzfoermigen
Zungenpapille bezeichneten Papilla fungiformis von Ratte,
Meerschweinchen, Nutria und Wasserschwein in lichtoptischer,
ultrastruktureller und rasterelektronenmikro- skopischer Sicht. Die
vergleichende Darstellung der Ausformung der Papille, der Art der
Epithel- und Bindegewebsbeziehung, der Modus der Gefass- und
Nerven- versorgung soll der Klarung der Fragen dienen, ob
einerseits bei nahe verwandten Formen ein einheitliches Bauprinzip
fur die Papilla fungiformis vorliegt, und ob andererseits mit der
Zunahme der Koerpergroesse (Vergleich zwischen Meerschwein- chen
und Wasserschwein, dem groessten rezenten Nager)
Proportionsverschie- bungen in der Papillenarchitektur einhergehen.
Die anatomisch-physiologischen Betrachtungen uber die Warme- und
Kalteempfindungen der Zunge von Rein (1925) und Strughold (1925)
sollen mit der Art und Lokalisation der Nerven- endkoerperehen
innerhalb der Bindegewebspapille bei den untersuchten Formen in
Beziehung gesetzt, die Funktion der Papilla fungiformis als Organ
der Zungen- oberflache spezifizieren. Material und Methode Die
Papilla fungiformis der Zungenspitze und des vorderen
Zungendrittels von Ratte (4oe) (Rattus norvegicus albino Wistar),
Meerschweinchen (2 Cjl) (Cavia aperea f. porcellus) und Nutria (2 )
(Myocastor coypus) wurden untersucht. Um die Morphologie der
Papille auf oe ihre Artspezifitat und Groessenbeziehung hin zu
uberprufen, wurde als der nachste Verwandte des Meerschweinchens
und als groesster rezenter Nager das Wasserschwein (1 Cjl)
(Hydrochoerus capybara) als Vergleichstier herangezogen. Licht- und
Elektronenmikroskopie.
Urspriinglich verfolgte diese Arbeit nur die Absicht, die in meinem
1973 als Band 1 dieser Schriftenreihe verijffentlichten Buch "Die
Steuerbelastung der Untemehmung" in ihren Grundziigen dargel te
Teilsteuerrechnung zu dynamisieren und dadurch ihren
Anwendungsbereich auf mehrperiodige Kal kiile auszudehnen. 1m Laufe
der Untersuchungen zeigte sich jedoch bald, daB die dabei
auftretenden rechnerischen Grundsatzpl'obleme einer theoretischen
Basis bedurften, um zu abgesicherten Er.gebnissen zu gelangen. Aus
diesem Grunde hat Manfred Eisenach seine Darlegungen in den Rahmen
eines Bei trages zur entscheidungsorientierten Steuerplanung
gestellt. Die Analyse des Beziehungszusammenhangs zwischen
dynamischer Steuerbelastungsrechnung und steuerlicher Planung
ergab, daB eine als Entscheidungshilfe konzipierte
prospektiv-dynamische Teilsteuerrechnung mit (quantifizierender)
Steuer planung identisch ist; die damit gegebenen Moglichkeiten
sind ganz offen sichtlich von groBer praktischer Relevanz. Die
Zukunftsbezogenheit der Planung bedingt ein weites theoretisches
Unter suchungsfeld mit einer Vielfalt von Verankerungspunkten. In
erster Linie dadurch erkliirt sich der Umfang des Buches. Die
Ausfiihrungen konnten sich nur teilweise auf Voruntersuchungen
stiitzen; wegen des neuartigen Unter suchungsansatzes muBten viele
Probleme auch von Grund auf neu analysiert werden."
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Riementriebe, Kettentriebe, Kupplungen - Vortrage Und Diskussionsbeitrage Der Fachtagung "Antriebselemente", Essen 1953 (German, Paperback, Softcover Reprint of the Original 1st 1954 ed.)
K. Kollmann, K. H. Bussmann, A. Dahl, G Morchutt, B Arp, …
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R2,161
Discovery Miles 21 610
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Ships in 10 - 15 working days
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Jedem Ingenieur, der auf dem Gebiete der Antriebstedmik arbeitet,
sind aus seiner Berufsarbeit die Masdllnenelemente gelaufig. Leider
sind ihm aber in vielen Fallen gewisse, damit im Zusammenhang
stehende widttige wirtsdtaft- lidte Tatbestande nicht bekannt. Sie
kommen in den folgenden Zahlen zum Ausdruck: Unter den
Erzeugnisgruppen des gesamten Masdtinenbaues nehmen die An-
triebselemente - zu ihnen gehoeren Gleit- und Walzlager,
Kupplungen, Zahn- rader und andere Transmissionsteile - sowie die
Zahnradgetriebe und die stufenlos regelbaren Getriebe einen
beachtlidten Platz ein. Umsatzmassig reprasentierten sie im Jahre
1952 einen Wert von etwa 700 Millionen DM und standen damit in der
fadtlidten Unterteilung an vierter Stelle. Der Anteil der direkten
Ausfuhr in diesen Erzeugnissen betrug etwa 10 Prozent der vor-
genannten Summe. In der Gruppe Stahlgelenkketten wurde im Jahre
1952 ein Gesamtumsatzwert von rund 33 Millionen DM bei einem
Ausfuhranteil von 25 bis 30 Prozent erstellt. - Im gleidten
Zeitabsdtnitt beliefen sich die Gesamtumsatze der Her- steller von
Lederriemen auf etwa 20 Millionen DM. Hier betrugen die Export-
erloese etwa 10 Prozent dieser Summe. - Die Kautsdtukindustrie
beziffert ihre Gesamtumsatze in Gummikeilriemen auf etwa 19
Millionen DM fur das Jahr 1952, dabei lag der Wert der direkten
Ausfuhr bei etwa 15 Prozent. - In Textil- und Kunststoffflachriemen
wurden sdtatzungsweise noch groessere Um- satze erzielt.
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The Ballet Garden (Paperback)
Marcia Dale Weary; Marcia Dale Weary; Edited by Timothy C Eisenacher
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R255
Discovery Miles 2 550
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Ships in 10 - 15 working days
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