Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside, Third Edition comprehensively investigates key discoveries in the field of bone biology. New aspects of bone cancer biology are treated in new chapters covering exosomes, autophagy, and metabolism. These have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Third Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with 40% new material. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases. This revision opens the door to myeloma with two short chapters dedicated to this bone-associated disease.

Die tema van |Die ring| is die balans tussen die manlike en vroulike eienskappe in elke mens. Ons patriargale samelewing berus op 'n foutiewe aanname, glo die skrywer. Die manlike element is nie belangriker as die vroulike nie. Ten einde voluit te lewe, is 'n balans of eenwording tussen 'n individu se manlikheid en vroulikheid nodig.

A GUIDE TO NOISE IN MICROWAVE CIRCUITS A fulsome exploration of critical considerations in microwave circuit noise In A Guide to Noise in Microwave Circuits: Devices, Circuits, and Measurement, a team of distinguished researchers deliver a comprehensive introduction to noise in microwave circuits, with a strong focus on noise characterization of devices and circuits. The book describes fluctuations beginning with their physical origin and touches on the general description of noise in linear and non-linear circuits. Several chapters are devoted to the description of noise measurement -techniques and the interpretation of measured data. A full chapter is dedicated to noise sources as well, including thermal, shot, plasma, and current. A Guide to Noise in Microwave Circuits offers examples of measurement problems--like low noise block (LNB) of satellite television - and explores equipment and measurement methods, like the Y, cold source, and 7-state method. This book also includes: A thorough introduction to foundational terms in microwave circuit noise, including average values, amplitude distribution, autocorrelation, cross-correlation, and noise spectra Comprehensive explorations of common noise sources, including thermal noise, the Nyquist formula and thermal radiation, shot noise, plasma noise, and more Practical discussions of noise and linear networks, including narrowband noise In-depth examinations of calculation methods for noise quantities, including noise voltages, currents, and spectra, the noise correlation matrix, and the noise of simple passive networks Perfect for graduate students specializing in microwave and wireless electronics, A Guide to Noise in Microwave Circuits: Devices, Circuits, and Measurement will also earn a place in the libraries of professional engineers working in microwave or wireless circuits and system design.

There is very little argument that the world is facing severe environmental challenges. Ongoing air and water pollution, increasing energy consumption, and the depletion of natural resources have all placed considerable stress on the capacity of our environment to support the present quality of human life in a sustainable manner. Ensuring a Sustainable Future does what few previous works have: it examines these trends' disproportionate impact on the poor and the economically viable solutions that can serve to remedy them - solutions that simultaneously address environmental and economic problems. This gap in previous research, evidence, and writing has left low-income countries often unwilling to take on major environmental problems and many poor communities believing they faced impossible choices between improving the environment in which they live and increasing the jobs and income available. Bringing together evidence-based recommendations and in-depth case studies of successful policies and programs around the world, Ensuring a Sustainable Future examines innovative solutions to this crucial challenge. In doing so, it addresses a comprehensive range of environmental sustainability challenges affecting low-, middle-, and high-income countries.

The authors analyze the schism between accounting practitioners and academics, providing historical, philosophical, and political perspectives on this division. They support the efforts of the Accounting Education Change Commission in its call for sweeping changes in the scope and quality of accounting education. This schism originated before the turn of the century in the United States over concerns about the best preparation for professional accountants. Since that time, the nature of the schism has broadened considerably. Accounting has largely been taught in a structured framework, far removed from the dynamic and ill-structured situations resulting from environmental changes in which accounting is practiced. This gulf between accounting and practice reflects the schism today, which has become a division between individuals with different philosophical, economic, and political goals and attitudes. Nevertheless, the authors view the schism in a positive light--as a natural reflection of different ideas that lead to beneficial changes.

The authors begin with a philosophical perspective on the schism, as a division between opposing ideas, and deal with three areas of the accounting schism: education, practice, and standard-setting. The main focus is on education. The history of the schism is then delineated. Other views of the schism are considered next, including economic, political, and utilitarian. The function of the schism in the world of accounting is examined. Recent changes in the nature and complexity of the environment in which accounting is practiced are presented. This book is suitable for use in accounting theory and policy courses at the undergraduate and graduate levels and in accounting education seminars at the graduate level. In addition, the book should be of interest to accounting practitioners.

Sensory and Instrumental Evaluation of Alcoholic Beverages introduces the value of sensory analysis to the alcoholic beverage industry through the detailed lens of sensory analysis techniques. From traditional methods, to the most modern rapid methods, this book presents comprehensive insights and applications. Analytical methods for identifying and assessing the flavor compounds present in the beverages are included that address both volatile and non-volatile techniques, along with rapid methods of assessment. Case studies highlight the testing of different types of alcoholic beverages running the entire gamut of methods and the appropriate subset of methods. Also included is information of data analyses with the appropriate R-codes to allow practitioners to use the book as a handbook to analyze their own data.

Bone Cancer, Second Edition comprehensively investigates key discoveries in the field of bone biology over the last five years that have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Second Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with key chapters from the first edition, and offers numerous new chapters describing the new concepts of bone cancer biology and therapy, for both primary bone tumors as well as bone metastases. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases - from bench to bedside: development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases.

This book provides a broad-based approach to decision support systems (DSS) and their applications to finance and accounting. Heymann and Bloom go beyond mere description of DSS applications for particular system configurations to provide a comprehensive, technical analysis. They identify the changing roles over time of finance and accounting within organizational management and business control systems, outline the foundation of economic models within the objectives and methodology of scientific research, and provide an introduction to the logical structure of theoretical models in finance and accounting. The systems approach is examined as an alternative to the traditional decision model approach, and different tasks within a firm are presented in terms of complex and integrated management processes. In addition, the authors describe the role of DSS in the management of a firm, present specific applications of DSS in the areas of finance and accounting, and discuss the future outlook of DSS in computerized management systems as well as their possible effects on organizational structures and management control procedures.

Jacques Barzun, the noted Columbia University historian of ideas and culture, once described the feeling that some people experience when they come upon a new reference book. He wrote: "Hand over to one of us a new Dictionary, "Companion," or Guide, and our eyes first light up and then turn dreamy: we have seized the volume and are off, arm in arm with the guide i or companion. ..." The book now in your hands made my eyes light up. Thyroid Disorders with Cutaneous Manifestations is that kind of book. Heymann, who has been fascinated by this sometimes controversial subject for decades, has brought not only his own expertise, but that of many experts from the fields of the skin and the thyroid gland. Steven Jay Gould wrote about overlapping and nonoverlapping magisteria-this book demonstrates just how much important overlap there is. But it also covers the basics in such a way that dermatologists can find what they need to know about the thyroid and thyroidologists can find what they need to know about the skin. Thyroid Disorders with Cutaneous Manifestations falls neatly into the tra- tion of medical monographs that become standards. They fulfill the roles of gathering, digesting, and synthesizing current knowledge, and they do so in a way that review articles cannot approach and that the scientific literature is not designed to accomplish.

In this book, the author discusses a modern concept of general education that then helps to clarify both curricular and pedagogical deficits involved in conventional mathematics instruction. It provides an outline of an alternative mathematics instruction that can help to realize a general education and presents detailed arguments for seven interconnected objectives of a school system aiming at general education.

This volume examines issues of economic interest faced by Latin America economies in the late 20th Century. The fifteen chapters deal with macroeconomic problems, financial crises, the development of trade and trade agreements and labor issues. Of particular interest are the chapters dealing with Argentina, which provide an absorbing background to the financial crisis faced today.

This will be the first time a volume will be compiled focusing on South American monkeys as models to address and test critical issues in the study of nonhuman primates. In addition, the volume will serve an important compliment to the book on Mesoamerican primates recently published in the series under the DIPR book series. The book will be of interest to a broad range of scientists in various disciplines, ranging from primatology, to animal behavior, animal ecology, conservation biology, veterinary science, animal husbandry, anthropology, and natural resource management. Moreover, although the volume will highlight South American primates, chapters will not simply review particular taxa or topics. Rather the focus of each chapter is to examine the nature and range of primate responses to changes in their ecological and social environments, and to use data on South American monkeys to address critical theoretical questions in the study of primate behavior, ecology, and conservation. Thus, we anticipate that the volume will be widely read by a broad range of students and researchers interested in prosimians, New World monkeys, Old World monkeys, apes, humans, as well as animal behavior and tropical biology.

Covering nearly 260 of the most common dermatologic conditions from A to Z, Treatment of Skin Disease, 6th Edition, by Drs. Mark G. Lebwohl, Warren R. Heymann, Ian Coulson, and Dedee Murrell, is your go-to resource for authoritative, evidence-based treatment strategies in your daily practice. This award-winning text provides guidance on the fast-moving dermatological therapy options for virtually any skin disease you're likely to encounter, including third-line and unusual therapies when initial options have not been successful. Summaries of each treatment strategy are accompanied by detailed discussions of treatment choices, with ratings on a consistent scale ranging from clinical studies to anecdotal reports. Puts every possible therapeutic option at your disposal - including management strategies, first- to third-line therapies, and off-label uses - for a truly complete guide to the vast array of dermatologic treatment options. Features 4 all-new chapters on COVID-19 dermatoses, including the associated pediatric multisystem inflammatory syndrome; DRESS syndrome; keratosis lichenoides chronica; and tinea corporis and tinea cruris. Presents information in a consistent, tabular format, with checklists of diagnostic and investigative pearls and color-coded boxes for quick reference. Provides more than 260 full-color clinical images of skin diseases, most of which are new to this edition. Offers the combined knowledge and expertise of the world's leading authorities in dermatology. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.