Comprehensive overview of different aspects of autophagy as it relates to neurodegenerative diseases. The pathogenesis of the main neurodegenerative disorders includes either the accumulation of altered or misfolded proteins or exposure to several toxics. Autophagy constitute one of the two principal cellular pathways implicate in the clearance of these material and can serve as a neuroprotective mechanism. Topics include: the role of autophagy in the brain, the role of autophagy in the principal neurodegenerative disorders, and the mechanism by which different molecules cause neurotoxicity and the role autophagy plays.

"At the center of the 2,000 mile U.S.-Mexico border, a sprawling transnational urban space has mushroomed into a metropolitan region with over two million people whose livelihoods depend on global manufacturing, cross-border trade, and border control jobs. Our volume advances knowledge on urban space, gender, education, security, and work, focusing on Ciudad Jurez, the export-processing (maquiladora) manufacturing capital of the Americas and the infamous site of femicide and outlier murder rates connected with arms and drug trafficking. Given global economic trends, this transnational urban region is a likely paradigmatic future for other world regions"--Provided by publisher.

Trade agreements have uncontested relevance as essential instruments governing international trade, yet little attention has been directed towards explaining differences in their content. Deep Integration in Latin American Trade Agreements analyzes the structure, nature, and characteristics of deep integration in trade agreements established by Latin American countries after the crises of 1982 and until 2020 with their regional and extra-regional partners. Ninfa M. Fuentes-Sosa argues that deep integration can be disaggregated into its institutional, operative, and horizontal dimensions (which differ regarding their functions and application level). Empirically, she demonstrates that trade provisions can be mapped, measured, and allocated into their corresponding dimension, providing an understanding of the deep integration structure in Latin America. She claims that the current structure poses challenges for deepening regionalism at a broad scale. Countries working on specific areas over time could diminish obstacles that have prevented them from achieving deeper trade integration. Providing an operational definition and measures of deep integration, this book will be of great interest to scholars, graduate students, and policymakers working in the field of international political economy, trade, and trade politics.

Trade agreements have uncontested relevance as essential instruments governing international trade, yet little attention has been directed towards explaining differences in their content. Deep Integration in Latin American Trade Agreements analyzes the structure, nature, and characteristics of deep integration in trade agreements established by Latin American countries after the crises of 1982 and until 2020 with their regional and extra-regional partners. Ninfa M. Fuentes-Sosa argues that deep integration can be disaggregated into its institutional, operative, and horizontal dimensions (which differ regarding their functions and application level). Empirically, she demonstrates that trade provisions can be mapped, measured, and allocated into their corresponding dimension, providing an understanding of the deep integration structure in Latin America. She claims that the current structure poses challenges for deepening regionalism at a broad scale. Countries working on specific areas over time could diminish obstacles that have prevented them from achieving deeper trade integration. Providing an operational definition and measures of deep integration, this book will be of great interest to scholars, graduate students, and policymakers working in the field of international political economy, trade, and trade politics.

Comprehensive overview of different aspects of autophagy as it relates to neurodegenerative diseases. The pathogenesis of the main neurodegenerative disorders includes either the accumulation of altered or misfolded proteins or exposure to several toxics. Autophagy constitute one of the two principal cellular pathways implicate in the clearance of these material and can serve as a neuroprotective mechanism. Topics include: the role of autophagy in the brain, the role of autophagy in the principal neurodegenerative disorders, and the mechanism by which different molecules cause neurotoxicity and the role autophagy plays.

"At the center of the 2,000 mile U.S.-Mexico border, a sprawling transnational urban space has mushroomed into a metropolitan region with over two million people whose livelihoods depend on global manufacturing, cross-border trade, and border control jobs. Our volume advances knowledge on urban space, gender, education, security, and work, focusing on Ciudad Jurez, the export-processing (maquiladora) manufacturing capital of the Americas and the infamous site of femicide and outlier murder rates connected with arms and drug trafficking. Given global economic trends, this transnational urban region is a likely paradigmatic future for other world regions"--Provided by publisher.

This book contains 15 fully peer-reviewed Invited Papers which were presented at the 13th Biennial European Conference on Fracture and is a companion to the CD-ROM http: //www.elsevier.com/locate/isbn/008043701xProceedings.
The organisers of the ECF 13 opted from the very beginning for an application-orientated conference, and consequently, this book contributes to the understanding of fracture phenomena, and disseminates fracture concepts and their application to the solution of engineering problems to practitioners in a wide range of fields.
The fields covered in this book can be broadly classified into: elastic-plastic fracture mechanics, fracture dynamics, fatigue and interactive processes, failure, structural integrity, coatings and materials, with applications to the following industrial sectors: transport, aerospace engineering, civil engineering, pipelines and automotive engineering.

A former X-Gamer (Jay Sole), now turned Radio DJ God. Finds unsuspecting love with an assertive posh Los Angeles Attorney (Samantha O'Malley). When she's dealt a timely card while pregnant, both their love and lives are pushed to the extreme. Jay comes to realize what true love is and in the process gains wisdom from an unsuspecting person. This is a small love story.

An ordinary man (Frank Johnson) is trying to deal with life after losing his job to "Budget cuts." Like so many in America these days, he copes in his own way. Frank rearranges his life through a new profound view of Feng Shui that he modifies to his expectations. With a sense of humor and his GPS, he navigates the balance of family, life, and unemployment in his new Feng Shui Kitchen? A seriously funny story that will make you cry from laughter Frank Johnson is the new blue collar hero of today.

A former X-Gamer (Jay Sole) turned Radio DJ God finds unsuspecting love with an assertive posh Los Angeles Attorney (Samantha O'Malley). When she's dealt a timely card while pregnant, both their love and lives are pushed to the extreme. Jay realizes what true love is and gains wisdom from an unsuspecting person. In the process Jay finds out that..."Faith Comes from the Heart, But Inspiration Comes from the Sole." This is a small love story.