The book presents select proceedings of the 8th International and 29th All India Manufacturing Technology, Design and Research (AIMTDR 2021) conference. It covers recent advances in the realms of electro- physical and chemical machining, machining optimization, surface morphology and sustainable machining. The contents also include precision engineering, metrology and quality, automation and smart systems, enterprise manufacturing intelligence, among others. This book will evoke interest among academicians, researchers, and practicing engineers who aspire to comprehend advances pertaining to the domain of modern machining processes

This study mainly emphasizes on pharmacophore features available in the immunosuppressant drugs, especially Calcineurin inhibitors for human prion diseases. The structural and functional properties of FK506/Tacrolimus - a drug used for treatment of human prion diseases were enhanced through pharmacophore-assisted molecular optimization approach. Important pharmacophore features responsible for interaction with active site and intramolecular structural stability were elucidated.