An essential component of inflammation is the migration of circulating leukocytes from blood into tissues. This process is characterized by a multistep paradigm of sequential cell adhesion and activation events that lead to the extravasation of specific leukocyte subsets to different tissues in health and disease. The first step of leukocyte extravasation, the rolling of leukocytes, is primarily mediated by the interactions of selectins and their ligands. It has recently become evident that fucosyltransferases are crucial for selectin ligand synthesis, inflammation, and skin homing. This book provides an in-depth overview of the mechanisms of leukocyte trafficking and of the molecular mechanisms of selectin/selectin ligand interactions and discusses options for pharmacological intervention to treat inflammatory diseases.

An essential component of inflammation is the migration of circulating leukocytes from blood into tissues. This process is characterized by a multistep paradigm of sequential cell adhesion and activation events that lead to the extravasation of specific leukocyte subsets to different tissues in health and disease. The first step of leukocyte extravasation, the rolling of leukocytes, is primarily mediated by the interactions of selectins and their ligands. It has recently become evident that fucosyltransferases are crucial for selectin ligand synthesis, inflammation, and skin homing. This book provides an in-depth overview of the mechanisms of leukocyte trafficking and of the molecular mechanisms of selectin/selectin ligand interactions and discusses options for pharmacological intervention to treat inflammatory diseases.

Thema des Romans "Malina" von Ingeborg Bachmann ist die Sprache: ihre Gesetze und Normen, Moeglichkeiten und Unmoeglichkeiten des Ausdrucks - von der Liebesmelodie bis zum Sprachmord... dies alles wird nicht beschrieben, sondern realisiert! Die Auseinandersetzung des Ichs mit der Macht der symbolischen Ordnung illustriert die Unterwerfung des Subjekts unter "herrschende" Sprachformen - ganz im Sinne von Jacques Lacans Theorie des "grossen Anderen". Erst an der Grenze des Sagbaren und mit dem buchstablichen Verschwinden des Subjekts im Text eroeffnet sich eine andere Dimension des Ausdrucks: in Textstruktur und Sprachrhythmus, in Klang, Musik und im Schweigen.

This Book Is In German. Due to the very old age and scarcity of this book, many of the pages may be hard to read due to the blurring of the original text.

This Book Is In German. Due to the very old age and scarcity of this book, many of the pages may be hard to read due to the blurring of the original text.