First Published in 1956 The Greek Tyrants is concerned primarily with an early period of Greek history, when the aristocracies which ruled in the eighth and seventh centuries were losing control of their cities and were very often overthrown by a tyranny, which in its turn gave way to the oligarchies and democracies of the classical period. The tyrants who seized power from time to time in various cities of Greece are analogous to the dictators of our own day and represented for the Greeks a political problem which is still topical: whether it is ever advantageous for a State to concentrate power in the hands of an individual. Those early tyrannies are an important phase of Greek political development: the author discusses here the various military, economic, political, and social factors of the situation which produce them. The book thus forms an introduction to the central period of Greek political history and will be of interest to scholars and researchers of political thought, ancient history, and Greek philosophy.

Turn back the clock with History Comics! In this graphic novel, experience the Stonewall Riots firsthand and meet iconic activists like Marsha P. Johnson and Sylvia Rivera. Three teenagers--Natalia, Jax, and Rashad--are magically transported from their modern lives to the legendary Stonewall Inn in the summer of 1969. Escorted by Natalia's eccentric abuela (and her pet cockatiel, Rocky), the friends experience the police raid firsthand and are thrown into the infamous riots that made the struggle for LGBTQ rights front-page news.

This unique volume traces the critically important pathway by which a "molecule" becomes an "anticancer agent. " The recognition following World War I that the administration of toxic chemicals such as nitrogen mustards in a controlled manner could shrink malignant tumor masses for relatively substantial periods of time gave great impetus to the search for molecules that would be lethal to specific cancer cells. Weare still actively engaged in that search today. The question is how to discover these "anticancer" molecules. Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval, Second Edition describes the evolution to the present of preclinical screening methods. The National Cancer Institute's high-throughput, in vitro disease-specific screen with 60 or more human tumor cell lines is used to search for molecules with novel mechanisms of action or activity against specific phenotypes. The Human Tumor Colony-Forming Assay (HTCA) uses fresh tumor biopsies as sources of cells that more nearly resemble the human disease. There is no doubt that the greatest successes of traditional chemotherapy have been in the leukemias and lymphomas. Since the earliest widely used in vivo drug screening models were the murine L 1210 and P388 leukemias, the community came to assume that these murine tumor models were appropriate to the discovery of "antileukemia" agents, but that other tumor models would be needed to discover drugs active against solid tumors.

Author John A. Andrews, son of the Caribbean soil, penetrates inside the belly of the underground. In an environment saturated with corruption, deception, duplicity, deceit, and inequities of all kinds, Andrews conceives an international, greed driven fiasco, embedded within the drug epidemic. Jamaican born, Drug Enforcement Agent "Rude Boy," is confronted with a massive impasse as three high ranking members of the Dragon Drug Cartel once assumed dead re-appear. Allied with the notorious Johnny "Too Bad," they return in an International face-off. Could Rude Buay survive this politically disturbing debacle?

This unique volume traces the critically important pathway by which a "molecule" becomes an "anticancer agent. " The recognition following World War I that the administration of toxic chemicals such as nitrogen mustards in a controlled manner could shrink malignant tumor masses for relatively substantial periods of time gave great impetus to the search for molecules that would be lethal to specific cancer cells. Weare still actively engaged in that search today. The question is how to discover these "anticancer" molecules. Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval, Second Edition describes the evolution to the present of preclinical screening methods. The National Cancer Institute's high-throughput, in vitro disease-specific screen with 60 or more human tumor cell lines is used to search for molecules with novel mechanisms of action or activity against specific phenotypes. The Human Tumor Colony-Forming Assay (HTCA) uses fresh tumor biopsies as sources of cells that more nearly resemble the human disease. There is no doubt that the greatest successes of traditional chemotherapy have been in the leukemias and lymphomas. Since the earliest widely used in vivo drug screening models were the murine L 1210 and P388 leukemias, the community came to assume that these murine tumor models were appropriate to the discovery of "antileukemia" agents, but that other tumor models would be needed to discover drugs active against solid tumors.