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Anticancer Drug Development Guide - Preclinical Screening, Clinical Trials, and Approval (Paperback, Softcover reprint of the original 1st ed. 2004)
Loot Price: R4,527
Discovery Miles 45 270
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Anticancer Drug Development Guide - Preclinical Screening, Clinical Trials, and Approval (Paperback, Softcover reprint of the original 1st ed. 2004)
Series: Cancer Drug Discovery and Development
Expected to ship within 10 - 15 working days
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This unique volume traces the critically important pathway by which
a "molecule" becomes an "anticancer agent. " The recognition
following World War I that the administration of toxic chemicals
such as nitrogen mustards in a controlled manner could shrink
malignant tumor masses for relatively substantial periods of time
gave great impetus to the search for molecules that would be lethal
to specific cancer cells. Weare still actively engaged in that
search today. The question is how to discover these "anticancer"
molecules. Anticancer Drug Development Guide: Preclinical
Screening, Clinical Trials, and Approval, Second Edition describes
the evolution to the present of preclinical screening methods. The
National Cancer Institute's high-throughput, in vitro
disease-specific screen with 60 or more human tumor cell lines is
used to search for molecules with novel mechanisms of action or
activity against specific phenotypes. The Human Tumor
Colony-Forming Assay (HTCA) uses fresh tumor biopsies as sources of
cells that more nearly resemble the human disease. There is no
doubt that the greatest successes of traditional chemotherapy have
been in the leukemias and lymphomas. Since the earliest widely used
in vivo drug screening models were the murine L 1210 and P388
leukemias, the community came to assume that these murine tumor
models were appropriate to the discovery of "antileukemia" agents,
but that other tumor models would be needed to discover drugs
active against solid tumors.
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