Can molecular mechanisms involved in neural development help us to understand, prevent and perhaps reverse the course of brain ageing and neurodegenerative disorders? Brain development and function require complex cellular and molecular processes controlled by a number of different signaling mechanisms. One such signaling mechanism, the Notch pathway, has been recognized as an important player in the regulation of cellfate decisions during early neural development. However, the action of this evolutionary conserved and widely used cell-cell interaction mechanism is not confined to the developing nervous system. In addition, recent studies have shown that elucidating the mechanism of Notch signaling and its role in the brain is important for our understanding of neurological disorders such as Alzheimer's disease and cerebral arteriopathy CADASIL.

In recent decades it has become increasingly urgent to protect human health and wellbeing from the possible negative consequences of man's economic activities, both at the actual production sites and in areas where the im pact is felt. These negative effects have gradually become more and more widespread, presenting a major hazard to the natural environment, taking on an international character, and assuming global proportions. For the countries of Europe and North America, transport of pollutants and acid rain across boundaries is a serious problem. After the Chernobyl reactor accident, regular measurements of radioactive isotopes became im perative. It is obvious that drastic measures, including steps taken on an interna tionallevel, are required to limit the negative anthropogenic impact on the environment. Under the conditions of this growing man-caused impact on nature, the existing ecological reserves of the biosphere should be husbanded especially carefully. We must determine the regimes of rational utilization of these reserves and of judicious management of the natural environment, thereby maintaining a high quality of the biosphere and preserving nature's regener ative capacity. Reliable methods should be developed to keep the environ ment from being overloaded and to safeguard the elements of the biosphere from injury. Given such a situation, it is of particular importance to have objective information about the critical factors of the human impact and the actual state of the biosphere, as well as to obtain forecasts of its future state.

Can molecular mechanisms involved in neural development help us to understand, prevent and perhaps reverse the course of brain ageing and neurodegenerative disorders? Brain development and function require complex cellular and molecular processes controlled by a number of different signaling mechanisms. One such signaling mechanism, the Notch pathway, has been recognized as an important player in the regulation of cellfate decisions during early neural development. However, the action of this evolutionary conserved and widely used cell-cell interaction mechanism is not confined to the developing nervous system. In addition, recent studies have shown that elucidating the mechanism of Notch signaling and its role in the brain is important for our understanding of neurological disorders such as Alzheimer's disease and cerebral arteriopathy CADASIL.

The necessity of eliminating the possibility of a large-scale nuclear conflict from the future of mankind is the most important problem of our times. There is no doubt that the probable aftereffects of such a conflict would by many times exceed the damage caused by the First and Second World Wars, the greatest in history. The question of the scale of the damage that would be inflicted upon liv ing nature by nuclear weapons has, however, not yet been fully clarified. It is clear that this damage would not be local, i.e., restricted to destruction in only the places of nuclear explosion. As a result of nuclear detonations, the atmosphere and hydrosphere would receive many harmful substances, including the radioactive waste products of nuclear reactions. These substances can be transferred by air flows and water currents over long distances, thus considerably increasing the area of harmful influence of nuclear bursts. There is no doubt that the indirect effects of nuclear warfare would inflict enor mous damage on mankind, since the present human society can only exist by a complicated system involving the production of foodstuffs, manufactured goods, medical supplies, etc. The destruction of even separate but important links of this system would bring about starvation, epidemics, and other calamities, which would spread to areas not directly involved in the nuclear conflict."

2015 BMA Medical Book Awards Highly Commended in Oncology Category! The Molecular Basis of Cancer arms you with the latest knowledge and cutting-edge advances in the battle against cancer. This thoroughly revised, comprehensive oncology reference explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of this disease. A team of leading experts thoroughly explains the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Detailed descriptions of topics from molecular abnormalities in common cancers to new approaches for cancer therapy equip you to understand and apply the complexities of ongoing research in everyday clinical application. Effectively determine the course of malignancy and design appropriate treatment protocols by understanding the scientific underpinnings of cancer. Visually grasp and retain difficult concepts easily thanks to a user-friendly format with abundant full-color figures. Find critical information quickly with chapters following a logical sequence that moves from pathogenesis to therapy. Stay current with the latest discoveries in molecular and genomic research. Sweeping revisions throughout include eight brand-new chapters on: Tumor Suppressor Genes; Inflammation and Cancer; Cancer Systems Biology: The Future; Biomarkers Assessing Risk of Cancer; Understanding and Using Information About Cancer Genomes; The Technology of Analyzing Nucleic Acids in Cancer; Molecular Abnormalities in Kidney Cancer; and Molecular Pathology. Access the entire text and illustrations online, fully searchable, at Expert Consult.

Southern Religion and Christian Diversity in the Twentieth Century is a collection of fifteen essays by award-winning scholar Wayne Flynt that explores and reveals the often-forgotten religious heterogeneity of the American South. Throughout its dramatic history, the American South has wrestled with issues such as poverty, social change, labor reform, civil rights, and party politics, and Flynt's writing reaffirms religion as the lens through which southerners understand and attempt to answer these contentious questions. In Southern Religion and Christian Diversity in the Twentieth Century, however, Flynt gently but persuasively dispels the myth-comforting to some and dismaying to others-of religion in the South as an inert cairn of reactionary conservatism. Flynt introduces a wealth of stories about individuals and communities of faith whose beliefs and actions map the South's web of theological fault lines. In the early twentieth century, North Carolinian pastor Alexander McKelway became a relentless crusader against the common practice of child labor. In 1972, Rev. Dr. Ruby Kile, in a time of segregated churches led by men, took the helm of the eight-member Powderly Faith Deliverance Center in Jefferson County, Alabama and built the fledgling group into a robust congregation with more than 700 black and white worshippers. Flynt also examines the role of religion in numerous pivotal court cases, such as the US Supreme Court school prayer case Engel v. Vitale, whose majority opinion was penned by Justice Hugo Black, an Alabamian. These fascinating case studies and many more illuminate a religious landscape of far more varied texture and complexity than is commonly believed. Southern Religion and Christian Diversity in the Twentieth Century offers much to readers and scholars interested in the South, religion, and theology. Writing with his hallmark wit, warmth, and erudition, Flynt's Southern Religion and Christian Diversity in the Twentieth Century is a vital record of gospel-inspired southerners whose stories revivify sclerotic assumptions about the narrow conformity of southern Christians.

Sold in Sixty Seconds is everything you need to know about broadcast advertising that really works. Learn what keeps listeners' attention--and what drives them away. Find out how to capture attention before the first word is spoken. Discover the secrets of working your advertising message into long-term memory so customers will think of you when they need your product or service. In a short-attention-span economy, the right jingle can mean the difference between an ad that works and an ad that's switched off. Did you know... 13% of listeners will change stations during the first ad* 93 listeners out of 100 will switch stations after four ads* The trend is for stations to pack more ads into less airtime Broadcast advertising is a game of seconds. A great jingle can give you the edge.You've got something to sell and a story to tell. And you've only got a minute - maybe less. Successful advertisers use music to set the stage because nothing can instantly grab attention and then stick in consumer memory like a great jingle. Nothing.

720 of the finest jokes in Hebrew. All jokes were collected via the humor site of israel - Humor.co.il