The molecular basis for the physiology of the brain has advanced enormously in the past twenty years with an influx of new information gleaned through technological developments in neuroimaging and molecular discoveries. Molecular Physiology and Metabolism of the Nervous System, authored by Gary A. Rosenberg, an authority on the physiology of brain fluids and metabolism, combines the classic physiology that dates back to the beginning of the nineteenth century with the advances in molecular sciences, providing a strong framework for understanding the diseases that are commonly treated by neurologists.
Molecular Physiology and Metabolism of the Nervous System focuses on the current neuropathology and implications of cerebrospinal fluid diseases and diseases of the blood-brain barrier: how the two affect stroke, infection, brain tumors, and increased intracranial pressure. The book discusses the effects of blood flow in stroke and dementia, the disruption of the blood-brain barrier in neuroinflammation, and the dysfunction due to brain edema and increased intracranial pressure.
Molecular Physiology and Metabolism of the Nervous System is necessary reading for neurologists, neuroscientists, and residents in neurology, neurosurgery, and psychiatry, giving them a strong grounding in physiology and metabolism that will aid them in diagnosis and treatment.

This book is based on lectures delivered at Harvard in the Spring of 1991 and at the University of Utah during the academic year 1992-93. Formally, the book assumes only general algebraic knowledge (rings, modules, groups, Lie algebras, functors etc.). It is helpful, however, to know some basics of algebraic geometry and representation theory. Each chapter begins with its own introduction, and most sections even have a short overview. The purpose of what follows is to explain the spirit of the book and how different parts are linked together without entering into details. The point of departure is the notion of the left spectrum of an associative ring, and the first natural steps of general theory of noncommutative affine, quasi-affine, and projective schemes. This material is presented in Chapter I. Further developments originated from the requirements of several important examples I tried to understand, to begin with the first Weyl algebra and the quantum plane. The book reflects these developments as I worked them out in reallife and in my lectures. In Chapter 11, we study the left spectrum and irreducible representations of a whole lot of rings which are of interest for modern mathematical physics. The dasses of rings we consider indude as special cases: quantum plane, algebra of q-differential operators, (quantum) Heisenberg and Weyl algebras, (quantum) enveloping algebra ofthe Lie algebra sl(2) , coordinate algebra of the quantum group SL(2), the twisted SL(2) of Woronowicz, so called dispin algebra and many others.

Abraham Rosenberg assembles the groundbreaking work of preeminent international scientists to provide the most current, state-of-the-art presentation of research in siabiology. This concise volume examines the historical development of the field and reviews current knowledge on the genetic, immunologic, oncologic, neurodevelopmental, pathogenic, and cell regulatory properties of sialic acid. Outstanding features of this work include exhaustive reference material and detailed information tables.

This fact-filled resource helps readers understand the issues surrounding wilderness, preservation, and conservation. Here, in a single, unbiased volume, can be found the views and opinions that will shape America's landscape for future generations. Government management of the public domain is detailed, as is federal legislation pertaining to the environment and wilderness areas. Biographical sketches of individuals who have influenced modern attitudes toward preservation and a detailed chronology of the events that have brought us to the present are also provided. In addition, annotated listings of organizations and resources are included to assist readers in further study. Wilderness Preservation delivers solid, useful information that will serve as a foundation for decision-making, research, or simply enhanced understanding of this critical subject. Includes biographical sketches of individuals who have influenced modern attitudes toward preservation Contains a detailed chronology of the events that have brought us the present

The standard-setting text in oncology for 40 years, DeVita, Hellman and Rosenberg's Cancer: Principles and Practice of Oncology, 12th Edition, provides authoritative guidance and strategies for managing every type of cancer by stage and presentation. Drs. Vincent T. DeVita, Jr., Theodore S. Lawrence, and Steven A. Rosenberg oversee an outstanding team of expert contributing authors who keep you up to date and fully informed in this fast-changing field. This award-winning reference is also continually updated on Health Library and VitalSource platforms for the life of the edition. Integrates basic science into individual cancer chapters for more efficient reference Features quarterly updates that include late-breaking developments in oncology such as new drugs and clinical trials, as well as new case studies and interactive algorithms Offers balanced, multidisciplinary advice from a surgeon, a medical oncologist, and a radiation oncologist Provides updated content on immunotherapy and genetics throughout Includes important related topics such as cancer screening and prevention, palliative care, supportive oncology, and quality of life issues Now available in a convenient single volume, or a seven-multivolume option for portability and ease of use Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

The standard-setting text in oncology for 40 years, DeVita, Hellman and Rosenberg's Cancer: Principles and Practice of Oncology, 12th Edition, provides authoritative guidance and strategies for managing every type of cancer by stage and presentation. Drs. Vincent T. DeVita, Jr., Theodore S. Lawrence, and Steven A. Rosenberg oversee an outstanding team of expert contributing authors who keep you up to date and fully informed in this fast-changing field. This award-winning reference is also continually updated on Health Library and VitalSource platforms for the life of the edition. Integrates basic science into individual cancer chapters for more efficient reference Features quarterly updates that include late-breaking developments in oncology such as new drugs and clinical trials, as well as new case studies and interactive algorithms Offers balanced, multidisciplinary advice from a surgeon, a medical oncologist, and a radiation oncologist Provides updated content on immunotherapy and genetics throughout Includes important related topics such as cancer screening and prevention, palliative care, supportive oncology, and quality of life issues Now available in a convenient single volume, or a seven-multivolume option for portability and ease of use Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

This encyclopedia examines the profound influence of folklore on literature. The more than 350 alphabetically arranged entries fall into four categories: writers and literary works that use folklore as a resource or source; concepts that make it easier to look at folklore and literature together; themes and characters that originated in oral literature but are also found in written literature; and scholars who have studied and contributed to the field of folklore and literature. The work concentrates on European and Western themes, including classical Greek and Roman. The introduction discusses the interest and connections between folklore and literature and ends with a bibliography".--"Outstanding Reference Sources : the 1999 Selection of New Titles", American Libraries, May 1999. Comp. by the Reference Sources Committee, RUSA, ALA.

By combining excerpts from key historical writings with editors' introductions and further reading material, Philosophy of Biology: An Anthology offers a comprehensive, accessible, and up-to-date collection of the field's most significant works.* Addresses central questions such as 'What is life?' and 'How did it begin?', and the most current research and arguments on evolution and developmental biology* Editorial notes throughout the text define, clarify, and qualify ideas, concepts and arguments* Includes material on evolutionary psychology and evolutionary developmental biology not found in other standard philosophy of biology anthologies* Further reading material assists novices in delving deeper into research in philosophy of biology

As the highly anticipated update to Lipid Second Messengers (CRC Press, 1999), Lipid-Mediating Signaling is a current and comprehensive overview of research methods used in lipid-mediated signal transduction. Pioneering experts provide a much-needed distillation of a decade's worth of advances in research techniques that are pertinent in understanding how lipid-mediated signal transduction ties to pathologic disorders. Part I describes methods used to identify activities of and assay the expression of different enzymes involved in lipid-mediated signaling. Part II highlights the use of mass spectrometry to ascertain the lipid content in various systems. Part III contains two chapters devoted to techniques used to determine the role of lipids in the activation of gene transcription. Part IV rounds out the book's solid coverage by focusing on methods used to assess fatty acid uptake and metabolism. Lipid-Mediating Signaling is an unrivaled reference for this rapidly expanding, yet resource-limited field, and it is a valuable resource for for cell biologists, biochemists, and pharmacologists, as well as for researchers studying signaling transduction.

John Andre was captured in September 1780, outside British lines, and was hanged as a spy. Forty years later, he was still so highly regarded that, in 1821, his body was exhumed and reburied in the Heroes' Corner of Westminster Abbey. This book argues that James Fenimore Cooper's second novel, The Spy, is an examination of the nature and character of clandestinity in which the author investigates the morality of deceit and disguised intentions in normal life as well as in wartime by using the Andre affair as background. A century later, The Spy was undiscovered by British spy novelists. The publication date of The Spy (1821--the year of Andre's reinterment) further suggests that this affair is really the impetus for Cooper's examination of the nature of spying. Cooper is usually acknowledged as the originator of the Western; one of the assertions of this book is that he is also the first spy novelist.

Abraham Rosenberg assembles the groundbreaking work of preeminent international scientists to provide the most current, state-of-the-art presentation of research in siabiology. This concise volume examines the historical development of the field and reviews current knowledge on the genetic, immunologic, oncologic, neurodevelopmental, pathogenic, and cell regulatory properties of sialic acid. Outstanding features of this work include exhaustive reference material and detailed information tables.

The first in over half a century to be devoted to a detailed analysis of the complete Beethoven sonatas for violin and piano, this book arose from the author's desire to pass on to a younger generation more than sixty years' experience as a practising musician and teacher. Professor Rostal addresses himself to professional and amateur musicians alike, to students and to listeners, all of whom will derive pleasure and enlightenment from his words. Each of the ten Sonatas is carefully discussed, the manuscripts and first and later editions meticulously compared. Musicians will find technical and interpretative problems approached and solved and the music-lover a helpful listener's guide to these ever-popular masterpieces. As the Amadeus Quartet's Preface says of this important book, It is a "must" for all students and performers, and is a "must" for all lovers of Beethoven.' A renowned violinist and teacher, Professor MAX ROSTAL studied music under Arnold Ros138> and Carl Flesch. Founder and President of the European String Teachers' Association, he has made many recordings and is the editor of numerous wirks in the violin repertoire.

Although the novel, Voyages et avantures de J aques Masse, caused some- thing of a stir during the first half of the eighteenth century, its author, Simon Tyssot de Patot (1655-1738), remained largely unknown in his lifetime, and it is only in this century that he has been recognized as one of the countless soldiers in the vast army of philosophes that assaulted the bastions of religious, political and social life in Europe of the late seven- 1 teenth and early eighteenth centuries. Tyssot was a Huguenot who lived most of his life in Holland where he pursued a career as professor of mathematics in the social and cultural 1 Tyssot and his work seem to have been first brought to the attention of modern writers by the German critics during their investigation of the type of desert island or robinsonade literature that preceded and followed Defoe's Robinson Crusoe. The earliest reference I have found occurs in A. Kippenberg, Robinson in Deutschland bis zur Insel Felsenburg (1713-43), Hanover, 1892, pp. 66-67. Tyssot's name and work appear to have been first linked with the development of socialism in A. Lichtenberger, Le Socialisme au XVIIIe siecle, Paris, 1895, p. 44. Tyssot's Voyages et avantures de Jaques Masse was discussed for its literary merits in A. LeBreton, Le Roman au dix- huitieme siecie, Paris, 1898. LeBreton did not know that Tyssot was the author.

It is generally agreed that great men transcend their time while ordinary men remain rooted in it. This is why, if we want to know what life was like in days gone by, we must study those who were most representative of their age, those individuals who, though they may have achieved a modicum of fame or notoriety, are now, because of their limited abilities and outlook, largely forgotten. The great figures involved in the political and religious controversies that took of the seventeenth century and the beginning place in Holland! towards the end of the eighteenth, men such as Bayle, Jurieu, Le Clerc and others who were in the forefront of what has been aptly termed as the "crise de la conscience europeenne," these figures have been the object of extensive investigation. The minor personages of this period, on the other hand, have received little attention. For this reason, in a previous study,2 I examined the life and work of one of these minor figures, and tried to show how he was representative of those French Huguenots who came to Holland in the latter half of the seventeenth century, who settled in relatively remote places, and who made an effort to integrate themselves and gain acceptance in Dutch provincial society.

This book is based on lectures delivered at Harvard in the Spring of 1991 and at the University of Utah during the academic year 1992-93. Formally, the book assumes only general algebraic knowledge (rings, modules, groups, Lie algebras, functors etc.). It is helpful, however, to know some basics of algebraic geometry and representation theory. Each chapter begins with its own introduction, and most sections even have a short overview. The purpose of what follows is to explain the spirit of the book and how different parts are linked together without entering into details. The point of departure is the notion of the left spectrum of an associative ring, and the first natural steps of general theory of noncommutative affine, quasi-affine, and projective schemes. This material is presented in Chapter I. Further developments originated from the requirements of several important examples I tried to understand, to begin with the first Weyl algebra and the quantum plane. The book reflects these developments as I worked them out in reallife and in my lectures. In Chapter 11, we study the left spectrum and irreducible representations of a whole lot of rings which are of interest for modern mathematical physics. The dasses of rings we consider indude as special cases: quantum plane, algebra of q-differential operators, (quantum) Heisenberg and Weyl algebras, (quantum) enveloping algebra ofthe Lie algebra sl(2) , coordinate algebra of the quantum group SL(2), the twisted SL(2) of Woronowicz, so called dispin algebra and many others.

Nearly 300 Recipes that Feature the Healthiest Foods from around the World Chef and author Grace O has traveled the world in search of delicious, good-for-you foods. Her passion for discovering food treasures from the Blue Zones and elsewhere, where people live longer, healthier lives, is the driving force behind FoodTrients.com and her new cookbook, Age-Defying Dishes of the World. In her third cookbook, Grace O delivers all the hallmarks of her two previous award-winning cookbooks, and more. In addition to over 200 easy-to-make recipes using everyday favorites, exotic ingredients, and superfoods from around the world, Age-Defying Dishes of the World includes healthy resources, helpful guides, and tips for improving your lifespan and "health-span." Grace O’s global approach to her age-fighting recipes ramps up the flavor profiles of each dish to entice food lovers everywhere. She takes classic recipes and gives them international twists with a few simple steps, creating very interesting meals. For example, people will love her global take on chicken soup with recipes developed with Chinese, French, Greek, Middle Eastern, Mexican, and Indian variations. She does the same thing with basic sauces, pesto, main dishes, pastas, and bowls, and includes recipes with African, Southeast Asian, Latin American, Polynesian, Scandinavian, European, and Australian ingredients. The book also features guides to key herbs and spices from around the globe, and to the top 50 foods for longevity, healthy sweeteners, cooking oils, ancient grains, and more. All proceeds from Age-Defying Dishes of the World will be donated to the Grace O Foundation, which supports educating the public about nutrition, working with other food-based non-profits, and participating in research that explores food and the diseases of aging.  

Recent scientific advances have revolutionized cancer research and practice, creating a body of molecular biology information that is important to research scientists and clinical oncologists alike. Cancer: Principles and Practice of Oncology: Primer of the Molecular Biology of Cancer, 3rd Edition, keeps you up to date with all that's new in this rapidly changing field. Derived from DeVita, Hellman, and Rosenberg's Cancer: Principles and Practice of Oncology - widely regarded as the definitive clinical reference in oncology - the third edition of this popular Primer provides a single-volume, highly focused reference on every important frontier in the molecular biology of cancer. Compiles the knowledge and experience of leading scientists and clinicians in the field. Provides separate chapters on each of the 18 most common cancer types, with state-of-the-art information on how molecular biology advances are impacting clinical practice. Includes a thorough chapter on genetic counseling and genetic testing to help you navigate the challenges and ethical dilemmas of cancer genetics. Covers key topics such as Hallmarks of Cancer, Precision Medicine in Oncology, Cancer Immunotherapy, Pharmacogenomics, and many more. Enrich Your Ebook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

Jesse James, General Custer, and Casey Jones. The Pony Express, The Momon handcart odyssey to Zion. The Forty-Niners pick-and-shovel pilgrimage to Mammon. These are the colorful stuff of Western American folklore, part of an original and vital heritage passed on through songs, tales, and dime novels in the last century, and movies, advertising, and television serials in our own. In The Code of the West folklorist Bruce Rosenberg takes a look at some of the most durable legends of frontier days, explores the origins of their popularity, and deciphers the messages or code they communicate. What emerges is a fuller understanding of American culture as a whole, for Rosenberg shows us that American attitudes toward the West have always been linked to the hopes, ideals, and aspirations of the nation."

Precision medicine is a rapidly-evolving field in the management of cancer. The use of novel molecular or genetic signatures in local-regional management is still in its infancy. Precision Radiation Oncology demystifies this state-of-the-art research and technology. By describing current existing clinical and pathologic features, and focusing on the ability to improve outcomes in cancer using radiation therapy, this book discusses incorporating novel genomic- or biology-based biomarkers in the treatment of patients moving radiation oncology into precision/personalized medicine. Precision Radiation Oncology provides readers with an overview of the new developments of precision medicine in radiation oncology, further advancing the integration of new research findings into individualized radiation therapy and its clinical applications.

A Guide-Ways to Succeed is a book of poems written to inspire, motivate, and encourage anyone who wishes to change direction and succeed in life. The poems can be the instruments by which students, parents, teachers, professors, or community leaders can discuss the poems as they apply the principles of everyday living. The guide instructs and explains in poetic form how to respond to different life situations and describes ways to make the right choices.

Suggestions for use of the guide are included, as is "A Prospectus for a School and a Potential Curriculum Designed to 'Rescue and Keep Youth from Crime.'" A list of possible vocations or careers is included that might help one's thinking and exploring career advantages. The poems make effective supplementary material for homes, religious institutions, middle and senior high school classrooms, or college instruction.

This exploration of the making of a legend compares the actual events surrounding duster's defeat with the imaginative account of the "Last Stand" as it developed in American folklore. The battle of the Little Big Horn is then compared with other great "epics of defeat" in terms of both the similarities of the narratives and the known facts about them. The other epic stories include the Biblical account of Saul and his losing struggle against the Philistines, Leonidas's defense of the pass at Thermopylae, the death of Roland in the Chanson de Roland, the Morte Arthure, and similar stories of great "losers" from Scandinavia, Serbia, England, and the Alamo.

The interaction between literary and oral folk versions is explicated both for Custer and for his counterparts in other cultures. Custer's defeat was celebrated by writers of various stripes including dime novelist Frederick Whittaker, poets Longfellow and Whitman, and by painters of all shades of talent. The other epics have also been treated in both high culture and popular culture forms. Certain aspects of the folk variants of the legend of the defeated hero are shown to exist in legends and anecdotes about such other charismatic figures as Presidents Lincoln and Kennedy.

Finally, the book reinterprets several epics in the light of these new findings. And it goes on to argue that the legend-making process is one of the fundamental processes of the human imagination--the dramatization of all reality. Custer is thus seen as one with many national heroes whose popularity persists despite all the known facts which seem to deflate them.

Custer and the Epic of Defeat is illustrated with realistic as well as fanciful portraits of the heroes discussed, with photographs of several "last stand" sites from the Little Big Horn to Mt. Gilboa, and with battle maps.

As the highly anticipated update to Lipid Second Messengers (CRC Press, 1999), Lipid-Mediating Signaling is a current and comprehensive overview of research methods used in lipid-mediated signal transduction. Pioneering experts provide a much-needed distillation of a decade s worth of advances in research techniques that are pertinent in understanding how lipid-mediated signal transduction ties to pathologic disorders.

Part I describes methods used to identify activities of and assay the expression of different enzymes involved in lipid-mediated signaling. Part II highlights the use of mass spectrometry to ascertain the lipid content in various systems. Part III contains two chapters devoted to techniques used to determine the role of lipids in the activation of gene transcription. Part IV rounds out the book s solid coverage by focusing on methods used to assess fatty acid uptake and metabolism.

Lipid-Mediating Signaling is an unrivaled reference for this rapidly expanding, yet resource-limited field, and it is a valuable resource for for cell biologists, biochemists, and pharmacologists, as well as for researchers studying signaling transduction.