This book brings together a selection of papers by George Gerstein, representing his long-term endeavor of making neuroscience into a more rigorous science inspired by physics, where he had his roots. Professor Gerstein was many years ahead of the field, consistently striving for quantitative analyses, mechanistic models, and conceptual clarity. In doing so, he pioneered Computational Neuroscience, many years before the term itself was born. The overarching goal of George Gerstein's research was to understand the functional organization of neuronal networks in the brain. The editors of this book have compiled a selection of George Gerstein's many seminal contributions to neuroscience--be they experimental, theoretical or computational--into a single, comprehensive volume .The aim is to provide readers with a fresh introduction of these various concepts in the original literature. The volume is organized in a series of chapters by subject, ordered in time, each one containing one or more of George Gerstein's papers.

There is a tradition of theoretical brain science which started in the forties (Wiener, McCulloch, Turing, Craik, Hebb). This was continued by a small number of people without interruption up to the present. It has definitely provided main guiding lines for brain science, the devel opment of which has been spectacular in the last decades. However, within the bulk of experimental neuroscience, the theoreticians some times had a difficult stand, since it was felt that the times were not ripe yet and the methods not yet available for a development of a true theoretical speciality in this field. Thus theory remained in the hands of a fairly small club which recruited its members from theoretical physicists, mathematicians and some experimentalists with amateurish theoretical leanings. The boom of approaches which go by the name of 'computational neuroscience', 'neuronal networks', 'associative mem ory', 'spinglass theory', 'parallel processing' etc. should not blind one for the fact that the group of people professionally interested in real istic models of brain function up to the present date remains rather small and suffers from a lack of professional organization. It was against this background that we decided to organize a meet ing on Theoretical Brain Science. The meeting was held April 18 - 20, 1990 and took place at Schloss Ringberg, West-Germany, a facility sponsored by the Max-Planck-Society.

The present collection of papers forms the Proceedings of the First Meeting on Brain Theory, held October 1-4, 1984 at the International Centre for Theoretical Physics in Trieste, Italy. The Meeting was organized with the aim of bringing together brain theorists who are willing to put their own research in the perspective of the general development of neuroscience. Such a meeting was considered necessary since the explosion of experi mental work in neuroscience during the last decades has not been accompanied by an adequate development on the theoretical side. The intensity of the discussions during the Meeting is prob ably reflected best in the report of the organizers, reprinted here following the Preface. During the Meeting it was decided that a workshop of this kind should be repeated at regular intervals of approximately 2 years. The International Centre for Theoretical Physics in Trieste has kindly agreed to act as host for future meetings. The present Meeting was supported by grants from the In ternational Centre for Theoretical Physics and the International School for Advanced Studies in Trieste, IBM-Germany through the "Stifterverband fur die Deutsche Wissenschaft" and the Max Planck-Institute for Biological Cybernetics.