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This new edition describes the role of heat shock proteins in the
life cycle of malaria parasites, particularly in the context of
intracellular parasite stages. Thoroughly revised, this work
provides a general introduction to the structural and functional
features of heat shock proteins with a special focus on their role
as molecular chaperones in ensuring protein quality control. The
emphasis is on the heat shock protein families from Plasmodium
falciparum, and their role in proteostasis and the development of
malaria pathology. Moreover, the authors explore the latest
prospects of targeting heat shock proteins in antimalarial drug
discovery either directly or in combination therapies. Readers will
experience a functional analysis of the individual families of heat
shock proteins and their cooperation in functional networks,
including both the parasite-resident proteome and the exportome
released into host cells during intracellular stages. Subcellular
and extracellular organelles such as the apicoplast and the
Maurer's Clefts associated with Plasmodium species are discussed in
detail. The book highlights the role of heat shock proteins in the
development and function of these structures. Biochemical expertise
and the inclusion of novel therapeutic solutions make this
collection a unique reference for experts in heat shock protein
research, parasitology and infectious diseases, cell stress,
molecular biology and drug discovery. Not least, advances in
malaria control will contribute to ending epidemics and ensuring
healthy lives in line with the UN Sustainable Development Goals.
This book describes the role of heat shock proteins in the life
cycle of malaria parasites. The work includes a general
introduction on the structural and functional features of heat
shock proteins. The main focus is on the role of heat shock protein
families from Plasmodium falciparum, their role in protein folding
and in the development of malaria pathology. The functions of
individual families of heat shock proteins from plasmodium species
and their cooperation in functional networks is described.
Subcellular and extracellular organelles such as the apicoplast and
the Maurer's Clefts which are associated with plasmodium species,
are discussed in detail. The role of heat shock proteins in the
development and function of these organelles structures are
highlighted. Although conceding that heat shock proteins may not be
ideal antimalarial drug targets, prospects of targeting heat shock
proteins in antimalarial drug discovery either directly and/or in
combination therapies are explored.
This new edition describes the role of heat shock proteins in the
life cycle of malaria parasites, particularly in the context of
intracellular parasite stages. Thoroughly revised, this work
provides a general introduction to the structural and functional
features of heat shock proteins with a special focus on their role
as molecular chaperones in ensuring protein quality control. The
emphasis is on the heat shock protein families from Plasmodium
falciparum, and their role in proteostasis and the development of
malaria pathology. Moreover, the authors explore the latest
prospects of targeting heat shock proteins in antimalarial drug
discovery either directly or in combination therapies. Readers will
experience a functional analysis of the individual families of heat
shock proteins and their cooperation in functional networks,
including both the parasite-resident proteome and the exportome
released into host cells during intracellular stages. Subcellular
and extracellular organelles such as the apicoplast and the
Maurer's Clefts associated with Plasmodium species are discussed in
detail. The book highlights the role of heat shock proteins in the
development and function of these structures. Biochemical expertise
and the inclusion of novel therapeutic solutions make this
collection a unique reference for experts in heat shock protein
research, parasitology and infectious diseases, cell stress,
molecular biology and drug discovery. Not least, advances in
malaria control will contribute to ending epidemics and ensuring
healthy lives in line with the UN Sustainable Development Goals.
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