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Despite the significant advances in cancer therapy made through
constant evaluation and analysis of treatment aftereffects, the
disease still remains one of the foremost causes of mortality
worldwide killing more than 12 million people annually. The prime
reason behind the failure of conventional chemotherapeutics which
are used as the chief regimen in the comprehensive treatment of
cancers is the development of chemoresistance. It can be either
intrinsic or acquired and is primarily mediated via different key
regulators like MDR, MAPK, NF- B, PI3K/Akt, Wnt signaling pathways
etc. Thus, agents which can target these regulatory elements or
pathways and in turn sensitize cancer cells to chemotherapy holds
immense prospect. However, there is barely such comprehensive work
available in scientific literature that explains how
chemosensitization of cancer cells functions using different drug
combinations and exhibit synergism. This book provides a detailed
description of chemoresistance and chemosensitization, targets for
chemosensitization and various approaches adapted in the process of
chemosensitization. Furthermore, the book explicates the role of
various chemosensitizers, both natural and synthetic in sensitizing
cancer cells and also details the current research findings on
chemosensitization of different cancer types in both pre-clinical
and clinical settings.
Development of cancer, a dreadful disease of mankind, is a
multi-stage process involving numerous molecular alterations at
both genomic and proteomic levels. Immense research for the past
several decades in the field of cancer identified many such
mutations and their role in carcinogenesis. Concept of 'fusion
genes' seeded way back in 20th century has now grown into a new
field of cancer research. However, there is a lack of knowledge
among scientists about these fusion genes and their importance in
cancer, which can be mainly attributed to unavailability of a
comprehensive book on this topic. Therefore, this book is first of
its kind and aims at giving a detailed idea on the formation of
gene fusions and their importance in the development and
progression of cancer; techniques to identify novel gene fusions;
and therapeutics available to target various fusion proteins and
their impact in cancer therapy by compiling the information from
the literature available till date.
An estimated 12.6 million people are diagnosed with cancer every
year and 7.6 million people die of the disease annually. Numerous
lines of evidence suggest that lifestyle and nutrition play an
important role in cancer development. As for nutrition, diets that
are rich in fruits and vegetables have been shown to lower the risk
of cancer incidence. In addition, several phytochemicals that are
present in fruits and vegetables have been scientifically
established to have properties that can prevent and treat this
malevolent disease.The primary aim of the book is to educate the
public about the benefits of fruits and vegetables as they relate
to cancer and their potential to contribute to the possibility of a
cancer-free life. The active ingredients and modes of actions of
fruits and vegetables are also discussed, along with their
chemo-preventive aspects.This clearly written, comprehensive guide
explains the properties of these natural foods and substances on a
cancer-by-cancer basis. Thus, this book not only informs the
general public about the anticancer properties of fruits and
vegetables but also provides a valuable reference for scientists
and other professionals working in this area.
Most therapeutics available today are highly toxic, very expensive
and exhibit minimum efficacy. The issue of toxicity is even more
critical for prevention than for therapy because the former
involves normal subjects. Thus, therapeutics that are safe and
affordable are needed for both prevention and therapy. Spices of
Southeast Asian origin, once employed for taste, appearance and
preservation of food, now appear to have therapeutic value for
humans. What the active principles in these spices are and how they
mediate their effect against various diseases are beginning to
emerge from extensive research carried out within the last
half-century. The current monograph is an attempt to address the
active constituents, their molecular targets and the therapeutic
uses of these spices.
Inflammation and Natural Products brings together research in the
area of the natural products and their anti-inflammatory action in
medical, nutraceutical and food products, addressing specific
chronic inflammatory diseases like cancer and the mechanistic
aspects of the mode of action of some key natural products.
Inflammation is a complicated process, driven by infection or
injury or genetic changes, which results in triggering signalling
cascades, activation of transcription factors, gene expression,
increased levels of inflammatory enzymes, and release of various
oxidants and pro-inflammatory molecules in inflammatory cells.
Excessive oxidants and inflammatory mediators have a harmful effect
on normal tissue, including toxicity, loss of barrier function,
abnormal cell proliferation, inhibiting normal function of tissues
and organs and finally leading to systemic disorders. The emerging
development of natural product formulations utilizing the unique
anti-inflammatory compounds such as polyphenols, polysaccharides,
terpenes, fatty acids, proteins and several other bioactive
components has shown notable successes. Inflammation and Natural
Products: Recent Development and Current Status provides a
comprehensive resource, ranging from detailed explanation on
inflammation to molecular docking strategies for naturally
occurring compounds with anti-inflammatory activity. It is useful
for graduate students, academic and professionals in the fields of
pharmaceutical and medical sciences and specialists from natural
product-related industries.
Turmeric belongs to the family Zingiberaceae and is a yellow spice
of high economic importance due to its medicinal value. Cultivated
in tropical and sub-tropical regions around the world, it is used
extensively as a colouring, flavouring and preserving agent. In
recent years, several drugs derived from natural products have been
developed and current drug research is actively investigating the
possible therapeutic roles of many Ayurvedic medicines, most
notable among those being examined is turmeric. The wide range of
pharmacological activities attributed to turmeric come mainly from
curcuminoids and two related compounds, demethoxycurcumin and
bisdemethoxycurcumin. This comprehensive book brings together the
research carried out on constituents obtained from turmeric and
highlights their chemical and biological activities. Comprising 17
chapters, each written by experts in their respective field and
curated by authorities, it will be invaluable to all those who are
involved in the production, processing, marketing, and the use of
turmeric. Appealing to researchers and professionals in natural
products, nutraceuticals and food chemists, this book is exposing
some of the myths and showing areas for possible future use.
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