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Biosensors are essential to an ever-expanding range of
applications, including healthcare; drug design; detection of
biological, chemical, and toxic agents; environmental monitoring;
biotechnology; aviation; physics; oceanography; and the protection
of civilian and engineering infrastructures. This book, like the
previous five books on biosensors by this author (and one by the
co-author), addresses the neglected areas of analyte-receptor
binding and dissociation kinetics occurring on biosensor surfaces.
Topics are covered in a comprehensive fashion, with homogeneous
presentation for the benefit of the reader. The contributors
address the economic aspects of biosensors and incorporate coverage
of biosensor fabrication and nanobiosensors, among other topics.
The comments, comparison, and discussion presented provides a
better perspective of where the field of biosensors is heading.
A Fractal Analysis of Chemical Kinetics with Applications to
Biological and Biosensor Interfaces analyzes the kinetics of
binding and dissociation of different analytes by different
biosensor techniques, demonstrating, and then comparing each other.
Emphasis is on newer instrumentation techniques, such as surface
plasmon resonance imaging (SPRi), and classical techniques, such as
surface plasmon resonance (SPR), and finally, DNA biosensors and
nanobiosensors. In addition, the closing chapter includes
discussion of biosensor economics.
"Biomarkers and Biosensors" offers thorough coverage of
biomarker/biosensor interaction, current research trends, and
future developments in applications of drug discovery. This book is
useful to researchers in this field as well as clinicians
interested in new developments in early detection and diagnosis of
disease or the mode of operation of biomarkers. "Biomarkers and
Biosensors" also emphasizes kinetics, and clearly delineates how
this influences the biomarker market.
Offersthorough coverage of the kinetics of biomarker interaction
with the biosensor surfaceProvides evidence-based approach to
evaluate effectivenessProvides pharmaceutical chemists the
possibilities and methodology in assessing the effectiveness of new
drugsProvides the information needed for the selection of the best
biomarker for a specific application"
Biosensors are finding increasing applications in different areas.
Over the last few years the areas where biosensors may be used
effectively has increased dramatically. This book like the previous
four books on analyte-receptor binding and dissociation kinetics by
this author addresses the often neglected area. The kinetics of
binding and dissociation in solution to appropriate receptors
immobilized on biosensor surfaces occurs under diffusional
limitations on structured surfaces. The receptors immobilized on
the biosensor surface contribute to the degree of heterogeneity on
the sensor chip surface.
The fractal analysis examples presented throughout the book provide
a convenient means to make quantitative the degree of heterogeneity
present on the sensor surface, and relates it to the binding and
dissociation rate coefficients. The fractal dimension is a
quantitative measure of the degree of heterogeneity present on the
biosensor surface. The book emphasizes medially-oriented examples.
The detection of disease-related analytes is also emphasized. The
intent being that if intractable and insidious diseases are
detected earlier, they will be controlled better, eventually
leading to a better prognosis. Chapter 3 is a new chapter that
emphasizes enhancing the relevant biosensor performance parameters
such as sensitivity, stability, selectivity, response time, etc.
As usual, as done in previous books by this author, the last
chapter provides an update of the economics involved in biosensors,
and the difficulties encounters in starting-up a biosensor company.
- Modelling of binding and dissociation kinetics of
analyte-receptor reactions on biosensor surfaces: provides physical
insights into these reactions occurring on biosensor surfaces. Very
few researchers even attempt to analyze the kinetics of these types
of reactions.
- Fractal analysis used to model the binding and dissociation
kinetics: original and unique approach.
- Economic analysis provided in the last chapter: helps balance the
book; besides providing much-needed information not available in
the open literature.
- Emphasis on improving biosensor performance parameters: helps
make biosensors better.
- Empahsis on medically-related analytes: helps in prognosis of
diseases.
The application of biosensors is expanding in different areas.
These are portable and convenient devices that permit the rapid,
accurate, and reliable detection of analytes of interest present
either in the atmosphere or in aqueous or in liquid phases. The
detection of glucose levels in blood for the effective management
of diabetes is one. Though different biosensors have been designed
for an increasing number of applications, the kinetics of binding
(and dissociation) of analytes by the receptors on the biosensor
surfaces has not been given enough attention in the open
literature. This is a very important area of investigation since it
significantly impacts biosensor performance parameters such as
stability, sensitivity, selectivity, response time, regenerability,
etc. Binding and Dissociation Kinetics for Different Biosensor
Applications Using Fractals addresses this critical need besides
helping to correct or demonstrate the need to modify the present
software available with commercial biosensors that determines the
kinetics of analyte-receptor reactions on biosensor surfaces.
* first book to provide detailed kinetic analysis of the binding
and dissociation reactions that are occuring on the biosensor
surface
* addresses the area of analyte-receptor binding and dissociation
kinetics occurring on biosensor surfaces
* provides physical insights into reactions occuring on biosensor
surfaces
Biosensors are portable and convenient devices that permit the
rapid and reliable analysis of substances. They are increasingly
used in healthcare, drug design, environmental monitoring and the
detection of biological, chemical, and toxic agents. Fractal
Binding and Dissociation Kinetics for Different Biosensor
Applications focuses on two areas of expanding biosensor
development that include (a) the detection of biological and
chemical pathogens in the atmosphere, and (b) biomedical
applications, especially in healthcare. The author provides
numerous examples of practical uses, particularly biomedical
applications and the detection of biological or chemical pathogens.
This book also contains valuable information dedicated to the
economics of biosensors. After reading this book, the reader will
gain invaluable insight into how biosensors work and how they may
be used more effectively.
* No other book provides a detailed kinetic analysis of the binding
and dissociation reactions occurring on the biosensor
surfaces
* Packed with examples of practical uses of biosensors
* Includes chapters dedicated to the economics of biosensors
This title brings to the attention of researchers in the industry,
and in academia, the application of fractals to help in modeling
the analyte/receptor binding and dissociation kinetics on biosensor
surfaces.
The work builds on that done in Engineering Biosensors: Kinetics
and Design Applications, published by Academic Press in 2002. In
particular, more examples are provided of where biosensors may be
effectively used. This sequel is extremely timely, given the
anticipation that the applications and reliance on biosensors will
increase due to the advances in miniaturization, (wireless)
communications, and the development of new materials (especially
biological and chemical). Other applications of biosensors on the
increase can be found in: the protection of civilian structures and
infrastructures; protection from possible biological and chemical
threats; health care; energy; food safety; and the environment to
name a few.
- Covers all areas of applications of biosensors
- No other book on biosensors describes the kinetics of
binding
- Provides numerous examples of where biosensors may be used
Biosensors are becoming increasingly important bioanalytical tools
in the pharmaceutical, biotechnology, food, and other consumer
oriented industries. The technology, though well developed in
Europe, is slowly developing and has begun to generate interest in
the United States only over the past couple of years. Research is
now being directed toward the development of biosensors that are
versatile, economical, and simple to use.
Engineering Biosensors is a comprehensive introduction to
biosensors that includes numerous illustrations to further explain
the main concepts and practical examples from existing literature.
It describes what biosensors are, where they are used, and how
their performance is affected by existing surface characteristics.
A better understanding of biosensors, as provided by this book,
will greatly assist in the design of new as well as the improvement
of existing biosensors. Readers are also provided with invaluable
and hard-to-find data on the economics of the biosensor market to
assist them in better understanding the market and where it is
heading.
This book covers the fundamentals of protein inactivation during
bioseparation and the effect on protein processing. Bioseparation
of Proteins is unique because it provides a background of the
bioseparation processes, and it is the first book available to
emphasize the influence of the different bioseparation processes on
protein inactivation.
Bioseparation of Proteins covers the extent, mechanisms of, and
control of protein inactivation during these processes along with
the subsequent and essential validation of these processes. The
book focuses on the avoidance of protein (biologicalproduct)
inactivation at each step in a bioprocess. It compares protein
inactivation exhibited during the different bioseparation processes
by different workers and provides a valuable framework for workers
in different areas interested in bioseparations.
Topics include separation and detection methods; estimates of
protein inactivation and an analysis of this problem for different
separation processes; strategies for avoiding inactivation; the
molecular basis of surface activity and protein adsorption, process
monitoring, and product validation techniques; and the economics of
various bioseparation processes and quality control procedures.
Key Features
* Protein inactivation and other aspects of biological stability
are critical to an effective bioseparation process; This book is a
detailed and critical review of the available literature in an area
that is essential to the effectiveness, validation, and economics
of bioseparation processes for drugs and other biological products;
Conveniently assembled under one cover, the survey of the
literature and resulting perspective will greatly assist engineers
and chemists in designingand improving their own processes; Key
features of the text include:
* detailed data on biological stability under various bioseparation
conditions
* extensive case studies from the literature on separation
processes, validation, and economics
* simplified analysis of protein refolding and inactivation
mechanisms
* consideration of adsorption theories and the effect of
heterogeneity
* coverage of both classical and novel bioseparation techniques,
including chromatographic procedures
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