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"Function dictates structure" is a classic paradigm reaffirmed in
Wolff's law of the skeletal system. A major question being
addressed by current research in biomechanics is whether this
doctrine also holds true for the cardiovascular system and
connective tissues. Taking a multidisciplinary approach to this
question has produced new insights into the sensors, signals, and
activators that produce remodeling and functional adaptation in
cardiac muscle, blood vessels, and bone, including important new
findings on the response of vascular endothelial cells to shear
stress. Other work focuses on the extent of remodeling and
adaptation processes in tendons, ligaments, and intervertebral
discs. Together with two companion volumes, "Computational
Biomechanics" and the "Data Book on Mechanical Properties of Living
Cells, Tissues, " "and Organs," this monograph will prove
invaluable to those working in fields ranging from medical science
and clinical medicine to biomedical engineering and applied
mechanics.
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