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Stem Cells in Medicine, Volume 199 in the Progress in Molecular
Biology and Translational Science series, provides the most topical
and informative research in the field of stem cells. Sections in
this new release update on an Introduction to stem cells, Stem cell
engineering, Xeno-free culture and proliferation of hPSCs on 2D
biomaterials, 3D scaffold preparation for stem cell culture and
differentiation, GMP grade production of hPSCs, Human hepatic stem
cell assay, Cardiomyocyte cell sheets derived from hPSCs and muscle
cells for myocardial infarction treatment, Stem cell therapy for
osteoarthritis, hPSC-derived RPE transplantation for the treatment
of macular degeneration, and much more. The book provides not only
fundamental aspects and cultural and production methods of stem
cells, but also the critical engineering aspects of stem cells such
as drug screening using hepatocytes and disease treatment by
transplantation of retinal pigment epithelium and cardiomyocytes
which are derived from human pluripotent stem cells.
Stem Cell Laboratory Techniques: A Guide for Researchers and
Students introduces the reader to stem cell culture, handling
techniques and versatile applications used by researchers. Sections
introduce stem cells, including definitions, types and basic use of
stem cells in biomedical science research. The book explains
laboratory procedures and techniques ranging from the extraction of
stem cells from animals, cell seeding and culture, harvest and
maintenance of stem cells, stem cell characterization, accurate
recording, quality control, and more. In addition, it guides
researchers on topics such as transcriptome analysis, proliferation
study analysis, and microphysiological study. Final sections cover
useful and recent applications in stem cells, such as gene editing
techniques and the preparation of stem cells for in vitro study, as
well as stem cell lab design and equipment used in the lab. Lastly,
human and animal research ethics are discussed.
Human pluripotent stem cells (hPSCs), which cover both human
embryonic stem cells (hESCs) and induced pluripotent stem cells
(iPSCs), show promise for drug discovery and regenerative medicine
applications. These stem cells cannot be cultured on conventional
tissue culture dishes but on biomaterials that have specific
interactions with the hPSCs. Differentiation is regulated by the
biological and physical cues conferred by the biomaterial. This
book provides a systematic treatment of these topics bridging the
gap between fundamental biomaterials research of stem cells and
their use in clinical trials. The author looks at hPSC culture on a
range of biomaterial substrates. Differentiation and control of
hESCs and iPSCs into cardiomyocytes, osteoblasts, neural lineages
and hepatocytes are covered. The author then considers their
translation into stem cell therapies and looks at clinical trials
across spinal cord injury, macular degeneration, bone disease and
myocardial infarction. Finally, a chapter on future directions
closes the book. By using this book, the reader will gain a robust
overview of current research and a clearer understanding of the
status of clinical trials for stem cell therapies.
L'etude du personnage juif dans la litterature n'a pas suscite
beaucoup d'interet en France jusqu'a present.Les recherches plus
recentes menees sont consacrees majoritairement a un auteur -tel
Balzac- et s'inscrivent dans le cadre de la connaissance litteraire
de cet auteur. Les auteurs traites sont des auteurs reconnus de la
grande litterature, et tout un pan de l'imaginaire du siecle
precedent echappe ainsi a ces recherches. Cette litterature, quel
que soit le nom qu'on lui donne -alimentaire, populaire, infra ou
para-litterature, de gare, etc. a touche et touche encore un grand
nombre de lecteurs.On dispose maintenant avec cet ouvrage d'une
etude montrant l'evolution des representations de l'image du juif
au long du XXeme siecle dans cette forme de litterature populaire
qu'est le roman policier, dans quelques-uns uns de ses differents
avatars, aventures, enigme, noir ou "polar," a tendance
fantastique, ou parodique, etc.. Les champs couverts sont ceux du
roman francophone europeen francais, belge, suisse."
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