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Understand Quantitative Radiobiology from a Radiation Biophysics
Perspective In the field of radiobiology, the linear-quadratic (LQ)
equation has become the standard for defining radiation-induced
cell killing. Radiotherapy Treatment Planning: Linear-Quadratic
Radiobiology describes tumor cell inactivation from a radiation
physics perspective and offers appropriate LQ parameters for
modeling tumor and normal tissue responses. Explore the Latest Cell
Killing Numbers for Defining Iso-Effective Cancer Treatments The
book compiles radiation mechanism information from biophysical
publications of the past 50 years, addressing how ionizing
radiation produces the killing of stem cells in human tumors. It
presents several physical and chemical parameters that can modulate
the radiation response of clonogenic cells in tumors. The authors
describe the use of the LQ model in basic radiation mechanism
studies with cells of relatively homogeneous radiation response and
then extend the model to the fitting of survival data generated
with heterogeneous cell populations (tumors). They briefly discuss
how to use the LQ model for predicting tumor (local) control
probability (TCP) and normal tissue complication probability
(NTCP). The book also examines potential molecular targets related
to alpha- and beta-inactivation and gives suggestions for further
molecular characterizations of these two independent processes.
Develop Efficacious, Patient-Friendly Treatments at Reduced Costs
Focusing on quantitative radiobiology in LQ formulation, this book
assists medical physicists and radiation oncologists in identifying
improved cancer treatments. It also encourages investigators to
translate potentially improved radiotherapy schedules based on TCP
and NTCP modeling into actual patient benefit.
Understand Quantitative Radiobiology from a Radiation Biophysics
Perspective In the field of radiobiology, the linear-quadratic (LQ)
equation has become the standard for defining radiation-induced
cell killing. Radiotherapy Treatment Planning: Linear-Quadratic
Radiobiology describes tumor cell inactivation from a radiation
physics perspective and offers appropriate LQ parameters for
modeling tumor and normal tissue responses. Explore the Latest Cell
Killing Numbers for Defining Iso-Effective Cancer Treatments The
book compiles radiation mechanism information from biophysical
publications of the past 50 years, addressing how ionizing
radiation produces the killing of stem cells in human tumors. It
presents several physical and chemical parameters that can modulate
the radiation response of clonogenic cells in tumors. The authors
describe the use of the LQ model in basic radiation mechanism
studies with cells of relatively homogeneous radiation response and
then extend the model to the fitting of survival data generated
with heterogeneous cell populations (tumors). They briefly discuss
how to use the LQ model for predicting tumor (local) control
probability (TCP) and normal tissue complication probability
(NTCP). The book also examines potential molecular targets related
to alpha- and beta-inactivation and gives suggestions for further
molecular characterizations of these two independent processes.
Develop Efficacious, Patient-Friendly Treatments at Reduced Costs
Focusing on quantitative radiobiology in LQ formulation, this book
assists medical physicists and radiation oncologists in identifying
improved cancer treatments. It also encourages investigators to
translate potentially improved radiotherapy schedules based on TCP
and NTCP modeling into actual patient benefit.
From the essential background physics and radiobiology to the
latest imaging and treatment modalities, the updated second edition
of Handbook of Radiotherapy Physics: Theory & Practice covers
all aspects of the subject. In Volume 1, Part A includes the
Interaction of Radiation with Matter (charged particles and
photons) and the Fundamentals of Dosimetry with an extensive
section on small-field physics. Part B covers Radiobiology with
increased emphasis on hypofractionation. Part C describes Equipment
for Imaging and Therapy including MR-guided linear accelerators.
Part D on Dose Measurement includes chapters on ionisation
chambers, solid-state detectors, film and gels, as well as a
detailed description and explanation of Codes of Practice for
Reference Dose Determination including detector correction factors
in small fields. Part E describes the properties of Clinical
(external) Beams. The various methods (or 'algorithms') for
Computing Doses in Patients irradiated by photon, electron and
proton beams are described in Part F with increased emphasis on
Monte-Carlo-based and grid-based deterministic algorithms. In
Volume 2, Part G covers all aspects of Treatment Planning including
CT-, MR- and Radionuclide-based patient imaging,
Intensity-Modulated Photon Beams, Electron and Proton Beams,
Stereotactic and Total Body Irradiation and the use of the
dosimetric and radiobiological metrics TCP and NTCP for plan
evaluation and optimisation. Quality Assurance fundamentals with
application to equipment and processes are covered in Part H.
Radionuclides, equipment and methods for Brachytherapy and Targeted
Molecular Therapy are covered in Parts I and J, respectively.
Finally, Part K is devoted to Radiation Protection of the public,
staff and patients. Extensive tables of Physical Constants, Photon,
Electron and Proton Interaction data, and typical Photon Beam and
Radionuclide data are given in Part L. Edited by recognised
authorities in the field, with individual chapters written by
renowned specialists, this second edition of Handbook of
Radiotherapy Physics provides the essential up-to-date theoretical
and practical knowledge to deliver safe and effective radiotherapy.
It will be of interest to clinical and research medical physicists,
radiation oncologists, radiation technologists, PhD and Master's
students.
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