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Radiotherapy Treatment Planning - Linear-Quadratic Radiobiology (Paperback)
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Radiotherapy Treatment Planning - Linear-Quadratic Radiobiology (Paperback)
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Understand Quantitative Radiobiology from a Radiation Biophysics
Perspective In the field of radiobiology, the linear-quadratic (LQ)
equation has become the standard for defining radiation-induced
cell killing. Radiotherapy Treatment Planning: Linear-Quadratic
Radiobiology describes tumor cell inactivation from a radiation
physics perspective and offers appropriate LQ parameters for
modeling tumor and normal tissue responses. Explore the Latest Cell
Killing Numbers for Defining Iso-Effective Cancer Treatments The
book compiles radiation mechanism information from biophysical
publications of the past 50 years, addressing how ionizing
radiation produces the killing of stem cells in human tumors. It
presents several physical and chemical parameters that can modulate
the radiation response of clonogenic cells in tumors. The authors
describe the use of the LQ model in basic radiation mechanism
studies with cells of relatively homogeneous radiation response and
then extend the model to the fitting of survival data generated
with heterogeneous cell populations (tumors). They briefly discuss
how to use the LQ model for predicting tumor (local) control
probability (TCP) and normal tissue complication probability
(NTCP). The book also examines potential molecular targets related
to alpha- and beta-inactivation and gives suggestions for further
molecular characterizations of these two independent processes.
Develop Efficacious, Patient-Friendly Treatments at Reduced Costs
Focusing on quantitative radiobiology in LQ formulation, this book
assists medical physicists and radiation oncologists in identifying
improved cancer treatments. It also encourages investigators to
translate potentially improved radiotherapy schedules based on TCP
and NTCP modeling into actual patient benefit.
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