This book summarizes 20 years of work on the kinetics of blood-brain transfer and metabolism mechanisms in mammalian brain. The substances affiliated with these mechanisms include glucose, amino acids, monocarboxylic acids, and oxygen. These substances are important to energy metabolism and neurotransmission in the mammalian brain at rest and during activation. To understand the processes addressed by these mechanisms, the book examines the kinetics of compartmentation and compartmental analysis, particularly as they relate to transporter, enzyme, and receptor function. Compartments are subsets of substances separated by transporters and receptors in membranes, and enzymes in cells. This book is divided in six major chapters covering compartmental analysis, kinetic analysis of transport and metabolism, blood-brain transfer and metabolism of glucose, amino acids, and oxygen, and amino acid metabolism and interaction of amino acid metabolites with receptors.

This book summarizes 20 years of work on the kinetics of blood-brain transfer and metabolism mechanisms in mammalian brain. The substances affiliated with these mechanisms include glucose, amino acids, monocarboxylic acids, and oxygen. These substances are important to energy metabolism and neurotransmission in the mammalian brain at rest and during activation.

To understand the processes addressed by these mechanisms, the book examines the kinetics of compartmentation and compartmental analysis, particularly as they relate to transporter, enzyme, and receptor function. Compartments are subsets of substances separated by transporters and receptors in membranes, and enzymes in cells.

This book is divided in six major chapters covering compartmental analysis, kinetic analysis of transport and metabolism, blood-brain transfer and metabolism of glucose, amino acids, and oxygen, and amino acid metabolism and interaction of amino acid metabolites with receptors.

What is human nature? How is language related to thought - and should the connection be investigated socially or scientifically? Is external reality coherent or fragmented? What are the foundations of rationality, and how trustworthy are they? Such questions have bedevilled thinkers for millennia. Contemporary scholars have harnessed enormous resources to find answers, yet their inquiry is invariably constrained by the tunnel vision of academic specialisation. This issue of The Dolphin seeks to establish common ground among the disciplines examining the mind-brain continuum. Among those meeting the editors' challenge to think outside the disciplinary box are Noam Chomsky, John Searle and Steven Pinker, as well as a dozen others from the fields of neuroscience, linguistics, philosophy, cognitive science, English, computer science and ethnography. The implicit framework that results should help researchers in all fields locate the diversity of human knowing within a joint ontological perspective.