This book summarizes 20 years of work on the kinetics of
blood-brain transfer and metabolism mechanisms in mammalian brain.
The substances affiliated with these mechanisms include glucose,
amino acids, monocarboxylic acids, and oxygen. These substances are
important to energy metabolism and neurotransmission in the
mammalian brain at rest and during activation.
To understand the processes addressed by these mechanisms, the
book examines the kinetics of compartmentation and compartmental
analysis, particularly as they relate to transporter, enzyme, and
receptor function. Compartments are subsets of substances separated
by transporters and receptors in membranes, and enzymes in
cells.
This book is divided in six major chapters covering
compartmental analysis, kinetic analysis of transport and
metabolism, blood-brain transfer and metabolism of glucose, amino
acids, and oxygen, and amino acid metabolism and interaction of
amino acid metabolites with receptors.
General
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