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During the past few years, a considerable number of monographs on
bone tumors have been published. They are mainly restricted to bone
tumors as clinical-pathological entities, since their diagnosis,
more than that of other tumors, requires the interdisciplinary
cooperation between orthopedic specialist, radiologist, and
pathologist. However, investiga tions concerning the histogenesis
of bone tumors are rather limited, although they might be helpful
in explaining the unique morphological heterogeneity of tumors of
the skeletal system. Furthermore, the histo genetic approach in the
study of bone tumors may facilitate the inter pretation of the
advanced cytobiological methods available for improv ing
classification and diagnosis. Therefore, this volume presents
recent pathological advances in the biological characterization of
bone tumors. A major chapter deals with the differential diagnosis
of Ewing's sarcoma as regards its demarcation from the so-called
neuroectodermal tumor of bone. The analysis of the ground
substances in bone-forming tumors may be helpful for their
classification. Therefore the volume includes a chapter on the
biochemical and histochemical analysis of different osteosarcoma
types. Recently it has become clear that in addition to different
collagen types which are not specific for bone tissue, several
bone-specific proteins occur, one of which is osteonectin. Its
distribu tion is obviously important for the classification and
diagnosis of osteo blastic tumors. Proliferative behavior is of
major importance for the diagnosis of malignant tumors.
1. 2 1. 1. Quantitative Bildanalyse in der Elektronenmikro- skopie
Morphometrische Methoden 3 1. 2. Aufbau des Auswertungssystems 6 1.
3. 2. Methoden 7 Anwendungsbeispiele 10 3. 3. 1.
Tierexperimentelles Material 10 3. 1. 1. Vergleichende
feinstrukturell-morphometrische und 10 biochemische Befunde an der
Rattenleber nach Gallengangsligatur 3. 1. 2. Ein EinfluB von
Praseodymnitrat auf die quantita- 12 tive Cytoarchitektur der
Rattenleberzelle 3. 1. 3. Der Effekt von Clofibrat auf die
Rattenleber. Ver- 13 gleichende feinstrukturell-morphometrische und
bio- chemische Befunde 3. 1. 4. Der Effekt von
N-methyl-N'-nitro-N-nitrosoguanidin 17 auf die Rattenleber 3. 1. 5.
Die quantitative Cytoarchitektur der Rattenleber 20 nach
Bleiintoxikation Menschliches Biopsiematerial 3. 2. 22 3. 2. 1.
Morphometrische Basiswerte der normalen mensch- 22 lichen Leber 3.
2. 2. Die quantitative Cytoarchitektur der menschlichen 26
Leberzelle bei chronisch aggressiver Hepatitis 3. 2. 3.
Morphometrische Befunde am normalen menschlichen 29 Herzmuskel 3.
3. Quantitativ-feinstrukturelle Befunde an experimen- 32 tell
erzeugten Tumoren im Drusenmagen der Ratte 4. SchluBbetrachtung 35
5. Literatur 37 43 6. Abbildungen - 1 - 1. Ein lei tung Seit
Einfuhrung manueller quantitativer Bildanalysev- fahren in der
elektronenmikroskopischen Auswertung von biologischem Material
durch Loud (1962) und Weibel (1963, 1966, 1969) sind mit dieser
Methode zunehmend gute Unter- suchungsergebnisse erzielt worden.
Die Quantifizierung von elektronenmikroskopischen Befunden scheint
besonders sinn- voll, weil pathologische Veranderungen von
biologischem Material insbesondere im feinstrukturellen Bereich
haufig mehr quantitiver als qualitativer Natur sind. Als besonders
geeignete Untersuchungsobjekte kommen Gewebesysteme in Frage, die
nicht isotrop aufgebaut sind.
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