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Thi's book collects the contributions to the NATO Advanced Research
WJrkshop on "FundaIrental Aspects of Quantum 'Iheory", held at the
Centro di Cultura Scientifica "Alessandro Volta", Villa Olma,
Carro, Italy, 2-7 September 1985. The rreeting was dedicated to the
rremory of the late pro- fessor Piero Caldirola, a prominent member
of the Physics Departrrent of the University of r1ilan and a native
of Como. The aim of the workshop has been to present several recent
experi- rrental results and theoretical developrrents concerning
the various fa- cets of quantum physics. The breadth of scope of
the rreeting was in accordance with Professor Caldirola's vast
scientific interests, and fostered communication among
experirrental physicists, theoretical and mathematical physicists,
and nEthematicians, working in different but related fields.
Indeed, lectu- rers endeavoured to make their contributions
understandable to people acquainted with the problem but not
necessarily familiar with the tech- nical details; and these
efforts were successful, as indicated by the frequent private
discussions which took place among participants belon- ging to
different breeds and brands. 1ne rreeting was made up of six
one-day sessions, each of them addres- sing to a specific aspect of
quantum theory: 1. General Problems and Crucial Experinents; with
emphasis on sin- gle-particle interference eh~rirrents of neutrons
and of photons, and on the rreasurerrent problem. 2. Quantization
and Stochastic Processes; including stochastic quan- tization of
gauge fields, stochastic description of supersyrnmetric fields,
quantum stochastic calculus and stochastic mechanics.
The papers collected in this volume were presented at the 4th
International Symposium on Mass Spectrometry in Biochemistry and
Medicine held at Riva del Garda, Italy in June 1977. This meeting
was organised by the Italian Group for Mass Spectrometry in
Biochemistry and Medicine. The group was founded in Milan, Italy,
in 1975 by researchers working in different fields (chemistry,
pharmacology, medicine, biology). The aim of the symposium was to
bring together people working in different branches of mass
spectrometry for mutual discussion, exchange of ideas and
experience. I wish to thank Mrs. Judy Baggot, Mrs. Donata Castoldi
and Miss Vanna Pistotti for their invaluable technical assistance
and countless efforts in the preparation of this volume. Alberto
Frigerio Milan, January, 1978 v CONTENTS Newer Aspects of the
Biotransformation of Carbamazepine: Structural Characterization of
Highly Polar Metabolites * * * * 1 W. J. Richter, P. Kriemler and
J. W. Faigle Distribution in Brain Areas of Carbamazepine and
Carbamazepine-lO,ll-epoxide in 6-Hydroxydopamine Pretreated Rats 15
C. Pantarotto, V. Crunelli, A. Quattrone, P. Negrini, A. Frigerio
and R. Samanin Specific Ion Detection of Aryloxy Beta Blocking
Drugs for Metabolic Fate Determinations- Applications to Alprenolol
in Rats and Dogs 29 T. Walle and K. Walle The Use of GC-MS in
Perinatal Pharmacology: The Metabolism and Pharmacokinetics of
Analgesic Drugs in Mothers and Their Babies * * * * * * * * 49 J.
Caldwell, L. J. Notarianni and L. A.
The papers collected in this volume were presented at the 5th
International Symposium on Mass Spectrometry in Biochemistry and
Medicine held at Rimini, Italy, in June 1978. This meeting was
organized by the Italian Group for Mass Spectrometry in
Biochemistry and Medicine, which was founded in Milan, Italy, in
1975 by researchers working in different fields (chemistry,
pharmacology, medicine, biology). I wish to thank Mrs. Anna
Bernard, Mrs. Donata Castoldi and Miss Vanna Pistotti for their
invaluable technical assistance and countless eff. orts in the
preparation of this volume. Alberto Frigerio Milan, March, 1979 v
Contents The Place of Mass Spectrometry in Drug Metabolism Studies
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . 1 A. Benakis In Vitro and in vivo Studies on the
Metabolism of Dibenzo/c, f 7-/-1,2 7 Diazepine . 9 A. Frigerio, P
Negrini, D Rotilio, A. De Pascale and E. Rossi Gas
Chromatographic-Mass Spectrometric Identification of Urinary
Metabolites of Propildazine in Rat 27 L. Simonotti, R. Colombo and
G. Pifferi Mass Spectrometric Characterization of Sydnocarb and its
Major Metabolites in Rat 43 J. Tamas, M. Polgar, G. Czira and L.
Vereczkey Metabolism of an Aryloxy Beta Blocking Drug 53 G. L.
Passetti, E. Grassi and A. Trebbi Isolation and Identification of
the Chloroform Soluble Urinary Metabolites of Suloctidil in Man . .
. 69 R. Roncucci, W. Cautreels, M. Martens, C. Gillet, K. Debast
and G. Lambelin Are Stable Sulfenic Acids Possible Metabolites of
Suloctidil? . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . 85 W. Cautreels, M. Martens, R. Roncucci, C.
Gillet, K. Debast and G."
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