The papers collected in this volume were presented at the 5th
International Symposium on Mass Spectrometry in Biochemistry and
Medicine held at Rimini, Italy, in June 1978. This meeting was
organized by the Italian Group for Mass Spectrometry in
Biochemistry and Medicine, which was founded in Milan, Italy, in
1975 by researchers working in different fields (chemistry,
pharmacology, medicine, biology). I wish to thank Mrs. Anna
Bernard, Mrs. Donata Castoldi and Miss Vanna Pistotti for their
invaluable technical assistance and countless eff. orts in the
preparation of this volume. Alberto Frigerio Milan, March, 1979 v
Contents The Place of Mass Spectrometry in Drug Metabolism Studies
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . 1 A. Benakis In Vitro and in vivo Studies on the
Metabolism of Dibenzo/c, f 7-/-1,2 7 Diazepine . 9 A. Frigerio, P
Negrini, D Rotilio, A. De Pascale and E. Rossi Gas
Chromatographic-Mass Spectrometric Identification of Urinary
Metabolites of Propildazine in Rat 27 L. Simonotti, R. Colombo and
G. Pifferi Mass Spectrometric Characterization of Sydnocarb and its
Major Metabolites in Rat 43 J. Tamas, M. Polgar, G. Czira and L.
Vereczkey Metabolism of an Aryloxy Beta Blocking Drug 53 G. L.
Passetti, E. Grassi and A. Trebbi Isolation and Identification of
the Chloroform Soluble Urinary Metabolites of Suloctidil in Man . .
. 69 R. Roncucci, W. Cautreels, M. Martens, C. Gillet, K. Debast
and G. Lambelin Are Stable Sulfenic Acids Possible Metabolites of
Suloctidil? . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . 85 W. Cautreels, M. Martens, R. Roncucci, C.
Gillet, K. Debast and G."
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