Thi's book collects the contributions to the NATO Advanced Research WJrkshop on "FundaIrental Aspects of Quantum 'Iheory", held at the Centro di Cultura Scientifica "Alessandro Volta", Villa Olma, Carro, Italy, 2-7 September 1985. The rreeting was dedicated to the rremory of the late pro- fessor Piero Caldirola, a prominent member of the Physics Departrrent of the University of r1ilan and a native of Como. The aim of the workshop has been to present several recent experi- rrental results and theoretical developrrents concerning the various fa- cets of quantum physics. The breadth of scope of the rreeting was in accordance with Professor Caldirola's vast scientific interests, and fostered communication among experirrental physicists, theoretical and mathematical physicists, and nEthematicians, working in different but related fields. Indeed, lectu- rers endeavoured to make their contributions understandable to people acquainted with the problem but not necessarily familiar with the tech- nical details; and these efforts were successful, as indicated by the frequent private discussions which took place among participants belon- ging to different breeds and brands. 1ne rreeting was made up of six one-day sessions, each of them addres- sing to a specific aspect of quantum theory: 1. General Problems and Crucial Experinents; with emphasis on sin- gle-particle interference eh~rirrents of neutrons and of photons, and on the rreasurerrent problem. 2. Quantization and Stochastic Processes; including stochastic quan- tization of gauge fields, stochastic description of supersyrnmetric fields, quantum stochastic calculus and stochastic mechanics.

The papers collected in this volume were presented at the 4th International Symposium on Mass Spectrometry in Biochemistry and Medicine held at Riva del Garda, Italy in June 1977. This meeting was organised by the Italian Group for Mass Spectrometry in Biochemistry and Medicine. The group was founded in Milan, Italy, in 1975 by researchers working in different fields (chemistry, pharmacology, medicine, biology). The aim of the symposium was to bring together people working in different branches of mass spectrometry for mutual discussion, exchange of ideas and experience. I wish to thank Mrs. Judy Baggot, Mrs. Donata Castoldi and Miss Vanna Pistotti for their invaluable technical assistance and countless efforts in the preparation of this volume. Alberto Frigerio Milan, January, 1978 v CONTENTS Newer Aspects of the Biotransformation of Carbamazepine: Structural Characterization of Highly Polar Metabolites * * * * 1 W. J. Richter, P. Kriemler and J. W. Faigle Distribution in Brain Areas of Carbamazepine and Carbamazepine-lO,ll-epoxide in 6-Hydroxydopamine Pretreated Rats 15 C. Pantarotto, V. Crunelli, A. Quattrone, P. Negrini, A. Frigerio and R. Samanin Specific Ion Detection of Aryloxy Beta Blocking Drugs for Metabolic Fate Determinations- Applications to Alprenolol in Rats and Dogs 29 T. Walle and K. Walle The Use of GC-MS in Perinatal Pharmacology: The Metabolism and Pharmacokinetics of Analgesic Drugs in Mothers and Their Babies * * * * * * * * 49 J. Caldwell, L. J. Notarianni and L. A.

The papers collected in this volume were presented at the 5th International Symposium on Mass Spectrometry in Biochemistry and Medicine held at Rimini, Italy, in June 1978. This meeting was organized by the Italian Group for Mass Spectrometry in Biochemistry and Medicine, which was founded in Milan, Italy, in 1975 by researchers working in different fields (chemistry, pharmacology, medicine, biology). I wish to thank Mrs. Anna Bernard, Mrs. Donata Castoldi and Miss Vanna Pistotti for their invaluable technical assistance and countless eff. orts in the preparation of this volume. Alberto Frigerio Milan, March, 1979 v Contents The Place of Mass Spectrometry in Drug Metabolism Studies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 A. Benakis In Vitro and in vivo Studies on the Metabolism of Dibenzo/c, f 7-/-1,2 7 Diazepine . 9 A. Frigerio, P Negrini, D Rotilio, A. De Pascale and E. Rossi Gas Chromatographic-Mass Spectrometric Identification of Urinary Metabolites of Propildazine in Rat 27 L. Simonotti, R. Colombo and G. Pifferi Mass Spectrometric Characterization of Sydnocarb and its Major Metabolites in Rat 43 J. Tamas, M. Polgar, G. Czira and L. Vereczkey Metabolism of an Aryloxy Beta Blocking Drug 53 G. L. Passetti, E. Grassi and A. Trebbi Isolation and Identification of the Chloroform Soluble Urinary Metabolites of Suloctidil in Man . . . 69 R. Roncucci, W. Cautreels, M. Martens, C. Gillet, K. Debast and G. Lambelin Are Stable Sulfenic Acids Possible Metabolites of Suloctidil? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 85 W. Cautreels, M. Martens, R. Roncucci, C. Gillet, K. Debast and G."